Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CSNK2A1
Approved Name	casein kinase 2, alpha 1 polypeptide
Location	20p13
Position	chr20:473591-543821, -1
External Links	HGNC: 2457 Entrez Gene: 1457 Ensembl: ENSG00000101266 UCSC: uc002wdx.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Byrne, E. M., 2014		P-value=0.20. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study
Mansour, H. A.,2009		Gene-based tests:X<sup>2</sup>=5.274, P-value = 0.136 in dominant model, X<sup>2</sup>=2.372, P-value = 0.551 in recessive model, X<sup>2</sup>=1.527, P-value = 0.687 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[21282530]	283
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[12700239]; IMP[11035045]; TAS[2174700]	27
GO:0005886	plasma membrane	cellular component	TAS[10799509]	360
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[10094392]	563
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0016055	Wnt signaling pathway	biological process	IEA	12
GO:0030307	positive regulation of cell growth	biological process	IDA[20625391]	8
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0031519	PcG protein complex	cellular component	IDA[21282530]	2
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0045732	positive regulation of protein catabolic process	biological process	IDA[20625391]	4
GO:0006468	protein phosphorylation	biological process	IDA[20625391]	42
GO:0061077	chaperone-mediated protein folding	biological process	TAS[19387550]	2
GO:0030177	positive regulation of Wnt signaling pathway	biological process	IMP[12700239]	4
GO:0051879	Hsp90 protein binding	molecular function	TAS[19387550]	4
GO:0016581	NuRD complex	cellular component	IDA[17827154]	1
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IMP[16193064]	5
GO:0008284	positive regulation of cell proliferation	biological process	IDA[20625391]	44
GO:0005829	cytosol	cellular component	TAS	223
GO:0016580	Sin3 complex	cellular component	IDA[17827154]	1
GO:0007165	signal transduction	biological process	TAS[2174700]	136
GO:0005524	ATP binding	molecular function	IEA	118
GO:0071174	mitotic spindle checkpoint	biological process	IMP[11704824]	1
GO:0047485	protein N-terminus binding	molecular function	IPI[11972058]	12
GO:0048511	rhythmic process	biological process	IEA	7

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04520	Adherens junction	11
hsa04310	Wnt signaling pathway	20

Gene related BioCarta pathways (count: 11)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 11)

ID	Name	No. of Genes in BDgene
wntPathway	WNT Signaling Pathway	5
ngfPathway	Nerve growth factor pathway (NGF)	5
il6Pathway	IL 6 signaling pathway	3
pdgfPathway	PDGF Signaling Pathway	5
TPOPathway	TPO Signaling Pathway	4
epoPathway	EPO Signaling Pathway	2
egfPathway	EGF Signaling Pathway	5
il2Pathway	IL 2 signaling pathway	3
Lis1Pathway	Lissencephaly gene (LIS1) in neuronal migration and development	3
insulinPathway	Insulin Signaling Pathway	4
igf1Pathway	IGF-1 Signaling Pathway	4

Gene related interactors from protein-protein interactions data in HPRD (count: 161)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CSNK2A1	HSPB8	NO	in vitro	11342557
CSNK2A1	SPIB	NO	in vitro;in vivo	8632909 , 10618498
CSNK2A1	PIN4	NO	in vitro;in vivo	12860119
CSNK2A1	SFRS12	NO	in vitro;in vivo;yeast 2-hybrid	14559993
CSNK2A1	CALM1	NO	in vitro;in vivo	11827172 , 8206911 , 1520270 , 8639568
CSNK2A1	CUX2	YES	in vitro	9446557
CSNK2A1	PTPN1	NO	in vitro;in vivo	8491187 , 9600099
CSNK2A1	HOXB7	NO	in vitro	11290787
CSNK2A1	PACS1	NO	in vitro;in vivo	14633983 , 16977309
CSNK2A1	PSMA3	NO	in vitro;in vivo	8619999
CSNK2A1	HNRNPA2B1	NO	in vivo	10381337
CSNK2A1	DVL3	NO	in vitro;in vivo	10806215
CSNK2A1	SPP1	NO	in vitro	8663267
CSNK2A1	HMOX2	NO	in vitro	14527438
CSNK2A1	UBE2R2	NO	in vitro;in vivo	12037680
CSNK2A1	HDAC1	NO	in vitro	11602581
CSNK2A1	HES6	YES	in vitro	12972610
CSNK2A1	NOL3	NO	in vitro;in vivo	12191471
CSNK2A1	STMN1	NO	in vitro;in vivo	8376365 , 8002936
CSNK2A1	SLC18A2	YES	in vitro	9045708
CSNK2A1	FLG	NO	in vitro	8270625
CSNK2A1	FAF1	NO	in vitro	11378439 , 11713579
CSNK2A1	GTF2A1	NO	in vitro;in vivo	11278496
CSNK2A1	GABRR2	NO	in vitro	12175859
CSNK2A1	ACCN3	NO	in vitro	9886053
CSNK2A1	TP53	NO	in vitro;in vivo	10747897 , 10348343 , 10884347 , 11709713 , 11883897 , 10951572 , 12628923
CSNK2A1	GMFB	NO	in vitro	9030586 , 7598724
CSNK2A1	NFKBIA	NO	in vitro;in vivo	8622692 , 10398585
CSNK2A1	SNCA	NO	in vitro;in vivo	10617630 , 10852916
CSNK2A1	PPP2R4	NO	in vitro;in vivo	9139659
CSNK2A1	FKBP3	NO	in vitro;in vivo	7689229
CSNK2A1	ZHX1	NO	yeast 2-hybrid	16169070
CSNK2A1	MAX	NO	in vitro;in vivo	11535131 , 8247525
CSNK2A1	HSP90AA1	YES	in vitro;in vivo	7794926 , 2492519
CSNK2A1	GAP43	NO	in vitro	1828073
CSNK2A1	HCLS1	NO	in vitro	10806407
CSNK2A1	SP1	NO	in vitro	9153193
CSNK2A1	YWHAQ	YES	in vivo	14675149
CSNK2A1	DDIT3	NO	in vitro	12876286
CSNK2A1	JUN	NO	in vitro;in vivo	9685505 , 1516134
CSNK2A1	APEX1	NO	in vitro	10023679
CSNK2A1	IGFBP3	NO	in vitro;in vivo	10650937
CSNK2A1	F5	NO	in vivo	9525959
CSNK2A1	HMGA1	NO	in vitro	11034995 , 2806554
CSNK2A1	LIG1	NO	in vivo	10523317 , 15302935
CSNK2A1	CSNK2B	YES	in vitro;in vivo	9188720 , 9571630 , 14667819
CSNK2A1	AIP	NO	in vitro	12361709
CSNK2A1	L1CAM	NO	in vitro	8592152
CSNK2A1	NAP1L4	NO	in vitro	10764593
CSNK2A1	RGS19	NO	in vivo	10760275 , 10993892
CSNK2A1	WEE1	NO	in vivo	16085715
CSNK2A1	PAK1	NO	in vivo	10938077
CSNK2A1	PTPRC	YES	in vivo	10066810
CSNK2A1	ACACA	NO	in vitro	2900140
CSNK2A1	EIF2S2	NO	in vitro	8024572
CSNK2A1	HSPH1	NO	in vitro	12558502 , 10772927
CSNK2A1	EIF5	NO	in vitro;in vivo	11861906
CSNK2A1	UBTF	NO	in vitro;in vivo	7651819
CSNK2A1	OGT	NO	in vitro	10753899
CSNK2A1	LGALS3	NO	in vitro;in vivo	10961987 , 8253806
CSNK2A1	STX1A	NO	in vitro;in vivo	10844023 , 9930733
CSNK2A1	MYB	NO	in vitro;in vivo	11313925
CSNK2A1	EEF1B2	NO	in vivo	14729942 , 15302935 , 8547318 , 15345747
CSNK2A1	CDK1	NO	in vitro;in vivo	7592773 , 1400350
CSNK2A1	PLEKHO1	NO	in vitro;in vivo;yeast 2-hybrid	10799509
CSNK2A1	SHOX	NO	in vitro	16325853
CSNK2A1	F11R	NO	in vitro	7646439
CSNK2A1	KLF1	NO	in vitro;in vivo	9722526
CSNK2A1	CTNNB1	NO	in vitro;in vivo	12432063 , 12700239
CSNK2A1	ATF1	NO	in vitro;in vivo	9685505
CSNK2A1	PRNP	NO	in vitro	11062072
CSNK2A1	XRCC1	NO	in vitro	15066279
CSNK2A1	PPP1R8	YES	in vitro	9407077
CSNK2A1	HMGA2	NO	in vitro	11034995
CSNK2A1	BRF1	NO	in vitro;in vivo	11997511
CSNK2A1	HDAC3	NO	in vitro	15805470
CSNK2A1	MYC	NO	in vivo	2663470
CSNK2A1	DVL1	YES	in vivo	10806215
CSNK2A1	RELA	NO	in vitro;in vivo	10938077
CSNK2A1	CTDP1	NO	in vitro;in vivo	12591939
CSNK2A1	BRCA1	NO	in vitro	10403822
CSNK2A1	RNF7	NO	in vitro	12748192
CSNK2A1	NKX2-5	NO	in vivo	9858576
CSNK2A1	GABRR1	YES	in vitro	12175859
CSNK2A1	PSMA4	YES	in vitro	8619999
CSNK2A1	RRAD	NO	in vitro	7876254 , 9677319
CSNK2A1	MGMT	NO	in vitro;in vivo	10667577
CSNK2A1	HDAC2	NO	in vitro;in vivo	12176973 , 12082111
CSNK2A1	YWHAB	NO	in vivo	15324660
CSNK2A1	IFI16	NO	in vitro	11115400
CSNK2A1	HIF1A	NO	in vitro	17382325
CSNK2A1	MEF2C	NO	in vitro;in vivo	8663403
CSNK2A1	PAFAH1B1	NO	in vitro	10491172
CSNK2A1	CDKN1A	NO	in vitro	11255227
CSNK2A1	EGR1	YES	in vitro;in vivo	8662759
CSNK2A1	FKBP4	NO	in vitro	9405642
CSNK2A1	KIF1C	NO	in vitro;in vivo	10559254
CSNK2A1	HSP90B1	YES	in vitro	11557039
CSNK2A1	NCL	YES	in vitro;in vivo	8663258
CSNK2A1	ABCA1	YES	in vitro	15218032
CSNK2A1	CDC37	NO	in vivo	12930845 , 15082798
CSNK2A1	HNRNPC	YES	in vitro;in vivo	12564933
CSNK2A1	CAV1	NO	in vitro	8058322
CSNK2A1	SPTBN1	NO	in vitro;in vivo	17088250
CSNK2A1	PIN1	NO	in vitro;in vivo	11940573
CSNK2A1	CFDP1	NO	in vitro	10350657
CSNK2A1	VDR	NO	in vitro	8622969
CSNK2A1	NOLC1	NO	in vitro	7657714
CSNK2A1	TH	YES	in vitro	14675149
CSNK2A1	MYCN	NO	in vitro;in vivo	1425701
CSNK2A1	FIBP	NO	in vitro;in vivo	12145206
CSNK2A1	TOP1	NO	in vitro;in vivo	2998765
CSNK2A1	PGR	NO	in vitro	7983041
CSNK2A1	BDP1	NO	in vitro;in vivo	15469824
CSNK2A1	PML	NO	in vitro	16873060
CSNK2A1	ERH	NO	in vitro	9074495
CSNK2A1	PTEN	NO	in vitro;in vivo	12297295
CSNK2A1	BID	NO	in vitro;in vivo	11583622
CSNK2A1	FGF1	NO	in vitro	12145206
CSNK2A1	MAZ	NO	in vitro;in vivo	10448092
CSNK2A1	SAT1	NO	in vitro	8954982
CSNK2A1	SUB1	NO	in vitro;in vivo	7809103
CSNK2A1	PPP1R2	YES	in vitro	8288648
CSNK2A1	EEF1D	NO	in vitro	10094407
CSNK2A1	XK	NO	in vivo	9647734
CSNK2A1	TOP2A	NO	in vivo	9804834 , 8939955 , 11940573
CSNK2A1	ARNT	NO	in vitro	16129408
CSNK2A1	MYF5	NO	in vitro	9461343
CSNK2A1	VAMP4	NO	in vitro	14608369 , 15345747
CSNK2A1	ATF2	NO	in vitro	9685505
CSNK2A1	AQP4	YES	in vitro	11742978
CSNK2A1	SRF	NO	in vitro	1740119 , 2046671
CSNK2A1	CD5	NO	in vitro;in vivo	9834084
CSNK2A1	MS4A1	NO	in vitro	7678037
CSNK2A1	RANGAP1	NO	in vitro	16428860
CSNK2A1	CLTB	NO	in vitro	3128543
CSNK2A1	ACAT2	NO	in vitro	16331323
CSNK2A1	PSEN2	NO	in vitro;in vivo	8972483 , 9990034 , 9558331
CSNK2A1	HSF1	NO	in vitro	12659875
CSNK2A1	VTN	NO	in vitro;in vivo	9733784
CSNK2A1	CASQ2	NO	in vitro;in vivo	1985907
CSNK2A1	GPI	NO	in vitro;in vivo	11004567
CSNK2A1	GYS1	NO	in vitro	2117608
CSNK2A1	CASP2	NO	in vitro;in vivo	16193064
CSNK2A1	IL16	NO	in vitro;in vivo	12450396
CSNK2A1	FOS	NO	in vitro	9685505
CSNK2A1	RPL5	NO	in vitro	10491318
CSNK2A1	CDH1	NO	in vitro;in vivo	10671552
CSNK2A1	SERPINF1	NO	in vitro	16322471
CSNK2A1	TSPY1	NO	in vitro	16426576
CSNK2A1	GTF2A1L	NO	in vitro	12107178
CSNK2A1	IRS1	NO	in vitro	8349691
CSNK2A1	NCF1	NO	in vitro	11535139 , 8089108
CSNK2A1	EIF2B5	NO	in vitro;in vivo	11500362
CSNK2A1	EIF4EBP1	NO	in vitro;in vivo	9806882 , 11146653 , 12588975
CSNK2A1	FGF2	NO	in vitro	12145206
CSNK2A1	WAS	NO	in vitro;in vivo	12769847
CSNK2A1	ARR3	NO	in vitro;in vivo	11877451
CSNK2A1	TCF7L2	YES	in vitro	11711551
CSNK2A1	C1R	NO	in vivo	8635594
CSNK2A1	SSRP1	NO	in vitro	15659405

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20pter-p12.3	chr20:0-9200000	1 (0/1/0)
20p13	chr20:0-5100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Description	Result Category
24687905	P-value=0.67. Gene-based tests show no significant association between this gene and SZ.	Negative
19839995	Gene-based tests:X<sup>2</sup>=3.126, P-value = 0.381 in recessive model in SZ/SZA, X<sup>2</sup>=2.752, P-value = 0.47 in dominant model in SZ/SZA, X<sup>2</sup>=1.354, P-value = 0.719 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
19839995	881	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
24687905	P-value=0.80. Gene-based tests show no significant association between this gene and MDD.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr20:473591..543821 View in gBrowse