Gene Report

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Basic Info

Approved Symbol	KCNIP4
Symbol Alias	CALP, KCHIP4, MGC44947
Approved Name	Kv channel interacting protein 4
Location	4p15.32
Position	chr4:20728616-21948799, -1
External Links	HGNC: 30083 Entrez Gene: 80333 Ensembl: ENSG00000185774 UCSC: uc003gqh.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs1425328	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008076	voltage-gated potassium channel complex	cellular component	ISS	8
GO:0005244	voltage-gated ion channel activity	molecular function	IEA	2
GO:0005267	potassium channel activity	molecular function	IEA	4
GO:0005886	plasma membrane	cellular component	IDA[11847232]; ISS	360
GO:0005509	calcium ion binding	molecular function	IDA[11847232]	50

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005783	endoplasmic reticulum	cellular component	IEA	49
GO:0030425	dendrite	cellular component	IEA	65
GO:0005737	cytoplasm	cellular component	IDA[11847232]	322
GO:1901379	regulation of potassium ion transmembrane transport	biological process	ISS	4
GO:0071805	potassium ion transmembrane transport	biological process	IEA	9
GO:0072659	protein localization to plasma membrane	biological process	ISS	9
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005829	cytosol	cellular component	ISS	223
GO:0015459	potassium channel regulator activity	molecular function	ISS	11

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KCNIP4	PSEN2	NO	in vivo;yeast 2-hybrid	11847232

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1425328	chr4:21307327 - 21307327(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs16870742	chr4:21298597 - 21298597(1)	intron_variant; NMD_transcript_variant
rs10516379	chr4:21299869 - 21299869(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs16870753	chr4:21303351 - 21303351(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs16870810	chr4:21318389 - 21318389(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p14-p15	chr4:11300000-41200000	1 (0/1/0)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:20728616..21948799 View in gBrowse