Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PPP2R5D
Symbol Alias	B56D
Approved Name	protein phosphatase 2, regulatory subunit B', delta
Previous Name	protein phosphatase 2, regulatory subunit B (B56), delta isoform, "protein phosphatase 2, regulatory subunit B', delta isoform"
Location	6p21.1
Position	chr6:42984499-43012342, 1
External Links	HGNC: 9312 Entrez Gene: 5528 Ensembl: ENSG00000112640 UCSC: uc003oth.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.02. This gene encodes for one of the four major Ser/Thr phosphatases, that is implicated in the negative control of cell growth and division.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 31)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0005634	nucleus	cellular component	TAS[8703017]	283
GO:0007399	nervous system development	biological process	TAS[8703017]	40

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS	8
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	IEA	5
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS	8
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	8
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0005829	cytosol	cellular component	TAS	223
GO:0006096	glycolytic process	biological process	TAS	1
GO:0034162	toll-like receptor 9 signaling pathway	biological process	TAS	7
GO:0009405	pathogenesis	biological process	TAS	13
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	8
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	8
GO:0000159	protein phosphatase type 2A complex	cellular component	IEA	5
GO:0006006	glucose metabolic process	biological process	TAS	10
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	10
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS	7
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS	7
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0034166	toll-like receptor 10 signaling pathway	biological process	TAS	6
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS	7
GO:0051403	stress-activated MAPK cascade	biological process	TAS	8
GO:0050790	regulation of catalytic activity	biological process	IEA; TAS[8703017]	11
GO:0034146	toll-like receptor 5 signaling pathway	biological process	TAS	6
GO:0016311	dephosphorylation	biological process	TAS	14
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0004722	protein serine/threonine phosphatase activity	molecular function	TAS	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP2R5D	CHEK2	NO	in vitro;yeast 2-hybrid	15380617
PPP2R5D	PPP4C	NO	in vivo	18715871
PPP2R5D	HAND2	NO	in vitro;yeast 2-hybrid	14636580
PPP2R5D	PPP2R1B	YES	yeast 2-hybrid	16541025
PPP2R5D	PPFIA1	YES	yeast 2-hybrid	16189514
PPP2R5D	HAND1	NO	in vitro	14636580
PPP2R5D	SGOL1	NO	in vivo;yeast 2-hybrid	16541024 , 16541025

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p21.1	chr6:40500000-46200000	1 (0/1/0)
6p21	chr6:30500000-46200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:42984499..43012342 View in gBrowse