GO Report

Basic Info
ID GO:0016021
Name integral component of membrane
Type cellular component
No. of Genes in BDgene  219
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
GO: 0016021: integral to membrane PBA paper Askland, K.,2009 NIMH Fisher's exact test Results given for gene sets with P < 0.01 from the NIMH PBA-CC data

GO related genes in BDgene (count: 219)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) Evidence[PMID]
TMEM217 transmembrane protein 217 6p21.31-p21.2 1(0/0/1) IEA
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) NAS[8145738]
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 8p21.3 3(2/1/0) IEA
CSMD3 CUB and Sushi multiple domains 3 8q23.3 1(0/1/0) IEA
NOTCH3 notch 3 19p13.2-p13.1 1(0/1/0) IEA
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 1p36.1 1(0/1/0) IEA
GPR124 adhesion G protein-coupled receptor A2 8p11.22 0 IEA
TAOK2 TAO kinase 2 16p11.2 1(0/1/0) IEA
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 3(1/2/0) IEA
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 11p15.1 1(0/1/0) IEA
HEPACAM2 HEPACAM family member 2 7q21.3 1(0/0/1) IEA
FGFR2 fibroblast growth factor receptor 2 10q25.3-q26 2(1/1/0) NAS[1697263]
EVC Ellis van Creveld syndrome 4p16 1(0/0/1) IEA
SYNE1 spectrin repeat containing, nuclear envelope 1 6q25.2 6(3/2/1) IDA[11792814]
OPA1 optic atrophy 1 (autosomal dominant) 3q29 1(0/1/0) IEA
PRLR prolactin receptor 5p14-p13 1(1/0/0) IEA
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 5q35 1(0/0/1) IEA
GGTA1P glycoprotein, alpha-galactosyltransferase 1 pseudogene 9q33.2 1(1/0/0) IEA
DPP10 dipeptidyl-peptidase 10 (non-functional) 2q14.1 3(2/1/0) IEA
PTPRT protein tyrosine phosphatase, receptor type, T 20q12-q13 2(0/1/1) NAS[9602027]
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 16q12.1 1(0/1/0) IEA
DIO2 deiodinase, iodothyronine, type II 14q24.2-q24.3 1(1/0/0) IEA
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 7q31 1(1/0/0) IBA
ABHD2 abhydrolase domain containing 2 15q26.1 2(0/1/1) IEA
LRRC15 leucine rich repeat containing 15 3q29 1(0/1/0) IEA
MALL mal, T-cell differentiation protein-like 2q13 1(0/1/0) IEA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 11q14.3-q21 1(0/1/0) NAS[10085079]
LMBR1L limb development membrane protein 1-like 12q13.12 1(0/0/1) IEA
CDH7 cadherin 7, type 2 18q22.1 1(0/0/1) IEA
THSD7A thrombospondin, type I, domain containing 7A 7p21.3 1(1/0/0) IEA
ADCY8 adenylate cyclase 8 (brain) 8q24 4(2/1/1) IEA
ASTN2 astrotactin 2 9q33 1(1/0/0) IEA
ZDHHC8 zinc finger, DHHC-type containing 8 22q11.21 1(0/1/0) IEA
SLC39A3 solute carrier family 39 (zinc transporter), member 3 19p13.3 1(0/1/0) IEA
SLCO3A1 solute carrier organic anion transporter family, member 3A1 15q26 2(1/1/0) IEA
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 12q24.31 1(0/1/0) IEA
BET1 Bet1 golgi vesicular membrane trafficking protein 7q21.1-q22 1(1/0/0) IEA
TMEM108 transmembrane protein 108 3q22.1 1(1/0/0) IEA
MPPE1 metallophosphoesterase 1 18p11.21 2(2/0/0) IEA
CLDN16 claudin 16 3q28 1(0/1/0) IEA
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 20p12.1 1(0/1/0) IEA
TYR tyrosinase 11q14.3 1(0/1/0) IEA
ALG10B ALG10B, alpha-1,2-glucosyltransferase 12q12 1(0/1/0) IEA
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 9q31.1 1(0/1/0) NAS[11880201]
MFSD11 major facilitator superfamily domain containing 11 17q25.1 1(0/1/0) IEA
VAMP7 vesicle-associated membrane protein 7 Xq28 and Yq12 2(0/2/0) IEA
TAAR1 trace amine associated receptor 1 6q23.1 1(0/1/0) IC[15718104]
EGFR epidermal growth factor receptor 7p12 1(0/0/1) IEA
PCDH15 protocadherin-related 15 10q21.1 4(2/1/1) IEA
ATP13A4 ATPase type 13A4 3q29 1(0/1/0) IEA
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2p15-p13 1(0/1/0) NAS[8101838]
ZDHHC13 zinc finger, DHHC-type containing 13 11p15.1 1(0/0/1) IEA
DIO3 deiodinase, iodothyronine, type III 14q32 1(0/1/0) IEA
ACE angiotensin I converting enzyme 17q23.3 5(2/3/0) IEA
RNF144B ring finger protein 144B 6p22.3 1(1/0/0) IEA
TPST2 tyrosylprotein sulfotransferase 2 22q12.1 2(1/0/1) IEA
PILRA paired immunoglobin-like type 2 receptor alpha 7q22.1 1(0/0/1) IEA
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 2q24.1 1(0/1/0) IEA
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 21q22.3 1(0/0/1) IEA
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 17p12 1(1/0/0) IEA
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 19q13.2 3(2/1/0) NAS[15260953]
EXTL1 exostosin-like glycosyltransferase 1 1p36.1 1(1/0/0) IEA
IL15RA interleukin 15 receptor, alpha 10p15.1 1(1/0/0) IEA
SCN8A sodium channel, voltage gated, type VIII alpha subunit 12q13.1 1(1/0/0) TAS[9828131]
THSD7B thrombospondin, type I, domain containing 7B 2q22.1 1(1/0/0) IEA
GPR78 G protein-coupled receptor 78 4p16.1 2(2/0/0) IEA
UPK3B uroplakin 3B 7q11.2 1(0/0/1) IEA
TAS1R3 taste receptor, type 1, member 3 1p36 1(0/0/1) IC[11917125]
LINGO2 leucine rich repeat and Ig domain containing 2 9p21.2 1(0/0/1) IEA
FZD2 frizzled class receptor 2 17q21.1 1(0/1/0) IBA
FAR2 fatty acyl CoA reductase 2 12p11.23 1(0/1/0) IEA
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 5p15.31 1(1/0/0) IEA
PCSK5 proprotein convertase subtilisin/kexin type 5 9q21.13 1(1/0/0) IEA
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 3(1/2/0) NAS[8906617]
LHFPL3 lipoma HMGIC fusion partner-like 3 7q22.2 1(0/1/0) IEA
MUC16 mucin 16, cell surface associated 19p13.2 1(0/0/1) IEA
FAAH fatty acid amide hydrolase 1p35-p34 2(0/2/0) IEA
MAOB monoamine oxidase B Xp11.4-p11.3 4(2/2/0) IEA
SEZ6L seizure related 6 homolog (mouse)-like 22q12.1 1(1/0/0) IEA
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 15q24 2(1/1/0) NAS[8906617]
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 20q13.33 1(1/0/0) IBA
SLC30A8 solute carrier family 30 (zinc transporter), member 8 8q24.11 1(1/0/0) IEA
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 18p11.2 1(1/0/0) IEA
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 7q21.12 1(1/0/0) IBA
PTPRE protein tyrosine phosphatase, receptor type, E 10q26 1(1/0/0) IEA
ADCY2 adenylate cyclase 2 (brain) 5p15.3 2(1/1/0) IEA
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0) TAS[8628395]
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 5p15.2 1(1/0/0) IEA
ASTN1 astrotactin 1 1q25.2 1(1/0/0) IEA
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 14q13.3 1(0/0/1) IEA
FAM20B family with sequence similarity 20, member B 1q25.2 1(0/1/0) IEA
TM4SF19 transmembrane 4 L six family member 19 3q29 1(0/1/0) IBA
SLC22A23 solute carrier family 22, member 23 6p25.2 1(1/0/0) IEA
MAOA monoamine oxidase A Xp11.4-p11.3 21(10/11/0) IEA
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 5p15.3 1(1/0/0) IEA
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0) IEA
PTPRO protein tyrosine phosphatase, receptor type, O 12p13-p12 1(0/1/0) TAS[10498613]
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 16p12.3 1(0/0/1) IEA
VAMP3 vesicle-associated membrane protein 3 1p36.23 1(0/1/0) IEA
GLT8D1 glycosyltransferase 8 domain containing 1 3p21.1 1(1/0/0) IEA
ADAM18 ADAM metallopeptidase domain 18 8p11.22 1(0/0/1) IEA
CRHR1 corticotropin releasing hormone receptor 1 17q21.31 4(2/2/0) IDA[23863939]
LAMP3 lysosomal-associated membrane protein 3 3q26.3-q27 1(1/0/0) IEA
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 11p13-p12 1(1/0/0) IEA
ZAN zonadhesin (gene/pseudogene) 7q22.1 1(0/0/1) IEA
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1p13 1(1/0/0) ISS
TMEM151B transmembrane protein 151B 6p21.1 1(1/0/0) IEA
TBXAS1 thromboxane A synthase 1 (platelet) 7q34-q35 1(0/1/0) IEA
SORCS2 sortilin-related VPS10 domain containing receptor 2 4p16.1 5(3/2/0) IEA
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 6q21 1(1/0/0) IDA[12089149]
ATRNL1 attractin-like 1 10q26 1(0/1/0) IEA
ADAM12 ADAM metallopeptidase domain 12 10q26 1(1/0/0) IEA
NCAM1 neural cell adhesion molecule 1 11q23.2 3(2/1/0) IEA
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 16p11.2 1(1/0/0) IEA
FMO5 flavin containing monooxygenase 5 1q21.1 1(1/0/0) IEA
ZDHHC19 zinc finger, DHHC-type containing 19 3q29 1(0/1/0) IEA
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2q12 1(0/0/1) IEA
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 2q24.3 1(1/0/0) NAS[9582303]
CERS3 ceramide synthase 3 15q26.3 1(0/0/1) IEA
ESR1 estrogen receptor 1 6q24-q27 1(0/1/0) IEA
FER1L6 fer-1-like family member 6 8q24.13 1(0/1/0) IEA
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 12q24.31 1(0/1/0) NAS[10022914]
DPP6 dipeptidyl-peptidase 6 7q36.2 2(1/1/0) IDA[18364354]
GLRA1 glycine receptor, alpha 1 5q33.1 1(1/0/0) NAS[15952785]
ALG9 ALG9, alpha-1,2-mannosyltransferase 11q23 1(0/1/0) IEA
OR3A1 olfactory receptor, family 3, subfamily A, member 1 17p13.3 1(0/0/1) IBA
SYNGR1 synaptogyrin 1 22q13 3(2/1/0) IEA; NAS[9760194]
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0) IDA[8392192]
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 3p22.2 2(1/1/0) IEA
TMEM132E transmembrane protein 132E 17q12 1(0/0/1) IEA
NRXN2 neurexin 2 11q13 1(1/0/0) IEA
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 8p11.21 3(1/2/0) NAS[8906617]
SERINC1 serine incorporator 1 6q22.32 1(1/0/0) IEA
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2p23.1 1(0/1/0) IEA
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 14q24.3 1(1/0/0) IEA
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 Xq26.2 1(0/0/1) IEA
CHL1 cell adhesion molecule L1-like 3p26 1(1/0/0) IEA
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 4q13 1(0/0/1) IEA
CDHR3 cadherin-related family member 3 7q22.2 1(0/1/0) IEA
SEC63 SEC63 homolog (S. cerevisiae) 6q21 1(1/0/0) IEA
GRM7 glutamate receptor, metabotropic 7 3p26-p25 3(2/1/0) IDA[12746871]
HCAR2 hydroxycarboxylic acid receptor 2 12q24.31 1(0/1/0) IEA
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 3p22.1 1(0/0/1) IEA
PVRIG poliovirus receptor related immunoglobulin domain containing 7q22.1 1(0/0/1) IEA
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 22q13.33 5(1/4/0) IDA[17628813]
EDAR ectodysplasin A receptor 2q13 1(0/1/0) NAS[10431241]
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 9q22.31 1(0/1/0) IEA
STX12 syntaxin 12 1p35.3 1(0/1/0) IBA
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 20q13.33 1(1/0/0) NAS[8906617]
CMKLR1 chemokine-like receptor 1 12q23.3 1(0/1/0) NAS[9603476]
OR4X2 olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene) 11p11.2 1(0/0/1) IBA
NMUR2 neuromedin U receptor 2 5q33.1 1(0/1/0) IDA[10899166]
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1q21.3 1(1/0/0) NAS[8906617]
LMAN2L lectin, mannose-binding 2-like 2q11.1 2(2/0/0) TAS[12609988]
XKR4 XK, Kell blood group complex subunit-related family, member 4 8q12.1 1(0/1/0) IEA
TSPAN8 tetraspanin 8 12q14.1-q21.1 2(1/0/1) IEA
DPY19L1 dpy-19-like 1 (C. elegans) 7p14.3-p14.2 1(0/0/1) IEA
PRSS55 protease, serine, 55 8p23.1 1(0/1/0) IEA
SYPL1 synaptophysin-like 1 7q22.2 1(1/0/0) TAS[1730063]
HLA-B major histocompatibility complex, class I, B 6p21.3 2(0/1/1) IEA
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1q21.3 7(1/6/0) IEA
PLD5 phospholipase D family, member 5 1q43 1(0/1/0) IEA
DPCR1 diffuse panbronchiolitis critical region 1 6p21.32 1(0/0/1) IEA
GLDN gliomedin 15q15.3 1(1/0/0) IEA
PROKR2 prokineticin receptor 2 20p12.3 1(1/0/0) IEA
CSMD1 CUB and Sushi multiple domains 1 8p23.2 4(2/1/1) IEA
DCC DCC netrin 1 receptor 18q21.1 2(1/1/0) IEA
COMT catechol-O-methyltransferase 22q11.21 28(14/14/0) IEA
DPY19L3 dpy-19-like 3 (C. elegans) 19q13.11 1(0/0/1) IEA
JAM3 junctional adhesion molecule 3 11q25 2(1/1/0) IEA
MCHR2 melanin-concentrating hormone receptor 2 6q16 1(1/0/0) IEA
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 4q26 1(1/0/0) IEA
EDA2R ectodysplasin A2 receptor Xq11.1 1(0/0/1) IC[12270937]
AGTR1 angiotensin II receptor, type 1 3q24 1(1/0/0) NAS[8135787]
LEPR leptin receptor 1p31 1(1/0/0) IEA
SMCO1 single-pass membrane protein with coiled-coil domains 1 3q29 1(0/1/0) IEA
FGFRL1 fibroblast growth factor receptor-like 1 4p16 1(0/0/1) IEA
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 15q13.2 1(0/1/0) IEA
KHDC1 KH homology domain containing 1 6q13 1(0/1/0) IEA
CADM2 cell adhesion molecule 2 3p12.2 1(0/1/0) IEA
DST dystonin 6p12.1 1(0/0/1) IEA
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2q11.2 1(1/0/0) IEA
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 8p21 3(0/3/0) NAS[8906617]
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 9q33.2 1(0/1/0) IBA
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 4p16.1 1(0/0/1) NAS[10860667]
SDK1 sidekick cell adhesion molecule 1 7p22.3 1(1/0/0) IEA
ARV1 ARV1 homolog (S. cerevisiae) 1q42.2 1(0/0/1) IEA
EVA1A eva-1 homolog A (C. elegans) 2p12 1(1/0/0) IEA
FZD3 frizzled class receptor 3 8p21 1(0/1/0) IBA
FRMD3 FERM domain containing 3 9q21.33 1(0/1/0) IEA
NRXN1 neurexin 1 2p16.3 1(1/0/0) IEA
CNTNAP5 contactin associated protein-like 5 2q14.1 2(0/2/0) IEA
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1p32.3 1(1/0/0) IC[11152697]
PLA2R1 phospholipase A2 receptor 1, 180kDa 2q23-q24 1(1/0/0) IEA
NRXN3 neurexin 3 14q31 2(2/0/0) IEA
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 15q13 1(1/0/0) NAS[10187864]
TAAR6 trace amine associated receptor 6 6q23.1 5(4/1/0) IC[15718104]
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 4q32.2 1(0/1/0) IEA
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 3p12.3 1(0/1/0) IEA
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 8q24 4(3/0/1) IBA
NALCN sodium leak channel, non selective 13q32.3 2(0/2/0) IEA
ANO3 anoctamin 3 11p14.2 1(1/0/0) IEA
TSPO translocator protein (18kDa) 22q13.3 3(1/2/0) IEA
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 16q24.3 1(1/0/0) IEA
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 11p14.2 1(1/0/0) IEA
XBP1 X-box binding protein 1 22q12.1 3(2/1/0) IEA
SGCZ sarcoglycan, zeta 8p22 1(0/0/1) IEA
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 7q31 1(1/0/0) IEA
TAAR8 trace amine associated receptor 8 6q23.2 1(0/1/0) IC[15718104]
POPDC3 popeye domain containing 3 6q21 1(1/0/0) NAS[10882522]
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2p21 1(0/1/0) IEA
VRK2 vaccinia related kinase 2 2p16.1 1(0/1/0) IEA
TMEM222 transmembrane protein 222 1p36.11 1(0/0/1) IEA
XXYLT1 xyloside xylosyltransferase 1 3q29 2(0/2/0) IEA
MPC2 mitochondrial pyruvate carrier 2 1q24 1(0/1/0) IEA
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 7q11.21 1(1/0/0) IEA
BVES blood vessel epicardial substance 6q21 1(1/0/0) IDA[16188940]; NAS[10441744]
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 13q12-q13 2(0/2/0) IEA
CD276 CD276 molecule 15q23-q24 1(0/1/0) NAS[15188059]