Gene Report

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Basic Info

Approved Symbol	NRXN2
Approved Name	neurexin 2
Name Alias	neurexin II
Location	11q13
Position	chr11:64606174-64723188, -1
External Links	HGNC: 8009 Entrez Gene: 9379 Ensembl: ENSG00000110076 UCSC: uc021qkw.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Interestingly, in four unrelated BD cases, we identified CNVs involving members of the neurexin family of genes, including a loss and a gain - both exonic - at NRXN1 (also see de novo loss at NRXN1 in another BD subject, below), an intronic deletion in NRXN3 and a partial duplication (exonic) of NRXN2.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA; ISS	116
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030534	adult behavior	biological process	IMP[21424692]	6
GO:0097104	postsynaptic membrane assembly	biological process	ISS	2
GO:0071625	vocalization behavior	biological process	IMP[21424692]	5
GO:0007269	neurotransmitter secretion	biological process	ISS	15
GO:0097119	postsynaptic density protein 95 clustering	biological process	ISS	3
GO:0097109	neuroligin family protein binding	molecular function	ISS; TAS[18923512]	3
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0097116	gephyrin clustering	biological process	ISS	2
GO:0007158	neuron cell-cell adhesion	biological process	TAS[18923512]	6
GO:0097118	neuroligin clustering	biological process	ISS	2
GO:0007416	synapse assembly	biological process	ISS	8
GO:0042297	vocal learning	biological process	IMP[21424692]	3
GO:0005246	calcium channel regulator activity	molecular function	ISS	8
GO:0035176	social behavior	biological process	IMP[21424692]	17
GO:0050839	cell adhesion molecule binding	molecular function	ISS; TAS[18923512]	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NRXN2	MACF1	NO	yeast 2-hybrid	12421765
NRXN2	CASK	NO	in vitro;yeast 2-hybrid	8786425
NRXN2	INADL	NO	in vitro;in vivo;yeast 2-hybrid	9647694
NRXN2	NLGN3	NO	in vitro	8576240
NRXN2	MLLT4	NO	yeast 2-hybrid	9707552
NRXN2	DDX24	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_32	chr11:64234575-64639365 (NCBI Build 36/hg18)	404000	11q13.1	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)
11p13-q13.3	chr11:31000000-70500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:64606174..64723188 View in gBrowse