Gene Report

Basic Info
Approved Symbol NRXN2
Approved Name neurexin 2
Name Alias neurexin II
Location 11q13
Position chr11:64606174-64723188, -1
External Links HGNC: 8009
Entrez Gene: 9379
Ensembl: ENSG00000110076
UCSC: uc021qkw.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Noor A., 2014 Interestingly, in four unrelated BD cases, we identified CNVs involving members of the neurexin family of genes, including a loss and a gain - both exonic - at NRXN1 (also see de novo loss at NRXN1 in another BD subject, below), an intronic deletion in NRXN3 and a partial duplication (exonic) of NRXN2. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 2)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:64606174..64723188 View in gBrowse
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