Gene Report

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Basic Info

Approved Symbol	NCAPD3
Symbol Alias	hCAP-D3, CAP-D3, hHCP-6, KIAA0056, FLJ42888, hcp-6
Approved Name	non-SMC condensin II complex, subunit D3
Location	11q25
Position	chr11:134150119-134225454, -1
External Links	HGNC: 28952 Entrez Gene: 23310 Ensembl: ENSG00000151503 UCSC: uc001qhd.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.01537, Product of P truncation <=0.01=0.00245, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0007076	mitotic chromosome condensation	biological process	IDA[14532007]	1

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[17268547]	563
GO:0000799	nuclear condensin complex	cellular component	IDA[14532007]	1
GO:0031618	nuclear pericentric heterochromatin	cellular component	IDA[20551165]	1
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0035064	methylated histone binding	molecular function	IDA[20622854]	3
GO:0051301	cell division	biological process	IEA	20
GO:0042585	germinal vesicle	cellular component	IEA	1
GO:0005654	nucleoplasm	cellular component	TAS	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NCAPD3	PRSS23	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00135, Product of P truncation <=0.01=0.00064, Product of P truncation <=0.001=0.00137 It showed evidence for association with SZ.	Positive

Gene relationship with MDD

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Region: chr11:134150119..134225454 View in gBrowse