Gene Report

Basic Info
Approved Symbol TYR
Symbol Alias OCAIA, OCA1A, OCA1
Approved Name tyrosinase
Name Alias oculocutaneous albinism IA
Location 11q14.3
Position chr11:89177452-89295759, 1
External Links HGNC: 12442
Entrez Gene: 7299
Ensembl: ENSG00000077498
UCSC: uc001pcs.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
De bruyn, A.,1994 Other variant: TYR_(GA)n - (CA)n Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 2)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 4)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr11:89177452..89295759 View in gBrowse
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