Gene Report

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Basic Info

Approved Symbol	ITGA9
Symbol Alias	RLC, ITGA4L, ALPHA-RLC
Approved Name	integrin, alpha 9
Name Alias	integrin, alpha 4-like
Location	3p21.3
Position	chr3:37452115-37823514, 1
External Links	HGNC: 6145 Entrez Gene: 3680 Ensembl: ENSG00000144668 UCSC: uc003chd.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Secolin, R.,2012	SNP: rs166508	The association results obtained for SNP rs166508 in the present study confirms previous evidence pointing to a candidate region for BPAD on ch 3p.22.3.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007411	axon guidance	biological process	TAS	60
GO:0007155	cell adhesion	biological process	IGI[21060781]	42

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005518	collagen binding	molecular function	IEA	4
GO:0008305	integrin complex	cellular component	TAS[8245132]	3
GO:0030593	neutrophil chemotaxis	biological process	IEA	8
GO:0042060	wound healing	biological process	IEA	9
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0043236	laminin binding	molecular function	IEA	2
GO:0034679	integrin alpha9-beta1 complex	cellular component	IEA	1
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	4
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0009925	basal plasma membrane	cellular component	IEA	3

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in BDgene
hsa04514	Cell adhesion molecules (CAMs)	14
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ITGA9	SPP1	NO	in vitro;in vivo	10593924
ITGA9	ITGB1	NO	in vitro;in vivo	10593924 , 8245132
ITGA9	FIGF	NO	in vitro;in vivo	15590642
ITGA9	SAT1	NO	in vivo;yeast 2-hybrid	15479742
ITGA9	PXN	NO	in vitro;in vivo	11598204

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs166508	chr3:37548944 - 37548944(1)	intron_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:37452115..37823514 View in gBrowse