Gene Report

Basic Info
Approved Symbol IL1RN
Symbol Alias IL1RA, ICIL-1RA, IL1F3, IRAP, IL-1RN, MGC10430
Approved Name interleukin 1 receptor antagonist
Name Alias interleukin-1 receptor antagonist protein, "intracellular interleukin-1 receptor antagonist"
Location 2q14.2
Position chr2:113107214-113134016, 1
External Links HGNC: 6000
Entrez Gene: 3557
Ensembl: ENSG00000136689
UCSC: uc002tjb.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Papiol, S.,2004 Haplotype: rs16944 - (IL1RN_intron 2_VNTR)(C-VNTR(A2))
Other variant: IL1RN_intron 2_VNTR
IL-1 cluster genetic variability may represent a shared genetic susceptibility factor both for schizophrenia and bipolar disorder. Positive Comment on Study
Rafiei, A., 2013 Other variant: IL1RN_intron 2_VNTR These findings suggest a positive association between VNTR polymorphism in IL1RN and BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 38)

GO terms by PBA (count: 3)

GO terms by database search (count: 35)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 9)

Gene relationship with MDD

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Region: chr2:113107214..113134016 View in gBrowse
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