Gene Report

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Basic Info

Approved Symbol	PPP3CC
Symbol Alias	CALNA3, PP2Bgamma
Approved Name	protein phosphatase 3, catalytic subunit, gamma isozyme
Previous Name	protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma), "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform"
Name Alias	calcineurin A gamma, "protein phosphatase 2B, catalytic subunit, gamma isoform"
Location	8p21.3
Position	chr8:22440819-22541142, 1
External Links	HGNC: 9316 Entrez Gene: 5533 Ensembl: ENSG00000120910 UCSC: uc011kzi.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		9 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.88, 2 LD blocks, 0.86 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005516	calmodulin binding	molecular function	IEA	20

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0006915	apoptotic process	biological process	TAS	39
GO:0097193	intrinsic apoptotic signaling pathway	biological process	TAS	8
GO:0005829	cytosol	cellular component	TAS	223
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0016311	dephosphorylation	biological process	IEA	14
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	biological process	TAS	6
GO:0004721	phosphoprotein phosphatase activity	molecular function	IEA	2

Gene related KEGG pathways (count: 10)

ID	Name	No. of Genes in BDgene
hsa04720	Long-term potentiation	13
hsa04020	Calcium signaling pathway	53
hsa04010	MAPK signaling pathway	39
hsa04210	Apoptosis	12

ID	Name	No. of Genes in BDgene
hsa04360	Axon guidance	16
hsa04662	B cell receptor signaling pathway	8
hsa04370	VEGF signaling pathway	11
hsa04650	Natural killer cell mediated cytotoxicity	13
hsa04660	T cell receptor signaling pathway	13
hsa04310	Wnt signaling pathway	20

Gene related BioCarta pathways (count: 12)

ID	Name	No. of Genes in BDgene	Brief Description
pgc1aPathway	Regulation of PGC-1a	4
fMLPpathway	fMLP induced chemokine gene expression in HMC-1 cells	4

ID	Name	No. of Genes in BDgene
gpcrPathway	Signaling Pathway from G-Protein Families	7
nfatPathway	NFAT and Hypertrophy of the heart (Transcription in the broken heart)	11
calcineurinPathway	Effects of calcineurin in Keratinocyte Differentiation	3
vipPathway	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	9
bcrPathway	BCR Signaling Pathway	4
tcrPathway	T Cell Receptor Signaling Pathway	7
ndkDynaminPathway	Endocytotic role of NDK, Phosphins and Dynamin	3
fcer1Pathway	Fc Epsilon Receptor I Signaling in Mast Cells	5
mef2dPathway	Role of MEF2D in T-cell Apoptosis	3
hdacPathway	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)	10

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP3CC	TGFBR1	NO	in vivo	15761153
PPP3CC	BMPR1B	NO	in vivo	15761153

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
PPP3CC-CC33	point mutation		1 (1/0/0)
PPP3CC-CCS3	point mutation		1 (1/0/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr8:22440819..22541142 View in gBrowse