Gene Report

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Basic Info

Approved Symbol	NRG3
Approved Name	neuregulin 3
Location	10q23.1
Position	chr10:81875314-82987179, 1
External Links	HGNC: 7999 Entrez Gene: 10718 Ensembl: ENSG00000185737 UCSC: uc001kco.2
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs17647803	SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as NRG3 (p=5.53Ã—10-6).	Negative	Comment on Study
Fallin, M. D.,2005		18 SNP typed, Median D'=0.14, Median r<sup>2</sup> =0.01, 10 LD blocks, 0.12 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	NAS[9275162]	158
GO:0005102	receptor binding	molecular function	IBA	37

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	NAS[9275162]	97
GO:0060596	mammary placode formation	biological process	IEA	1
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	molecular function	NAS[9275162]	2
GO:0008083	growth factor activity	molecular function	NAS[9275162]	15
GO:0035556	intracellular signal transduction	biological process	IBA	38
GO:0001558	regulation of cell growth	biological process	NAS[9275162]	7
GO:0005615	extracellular space	cellular component	IBA	85
GO:0030971	receptor tyrosine kinase binding	molecular function	NAS[9275162]	3
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	NAS[9275162]	5
GO:0048513	organ development	biological process	IBA	2
GO:0007389	pattern specification process	biological process	IEA	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04012	ErbB signaling pathway	13

Gene related BioCarta pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
agrPathway	Agrin in Postsynaptic Differentiation	8
erbB4pathway	g-Secretase mediated ErbB4 Signaling Pathway	2

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NRG3	ERBB4	YES	in vitro	9275162

Related other genetic factors

Gene related SNPs (count: 17)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17647803	chr10:81980465 - 81980465(1)	intron_variant; NMD_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs17725640	chr10:81930279 - 81930279(1)	intron_variant; NMD_transcript_variant
rs17647165	chr10:81949543 - 81949543(1)	intron_variant; NMD_transcript_variant
rs17098782	chr10:81936006 - 81936006(1)	intron_variant; NMD_transcript_variant
rs10509440	chr10:81976878 - 81976878(1)	intron_variant; NMD_transcript_variant
rs7099269	chr10:81959961 - 81959961(1)	intron_variant; NMD_transcript_variant
rs17647755	chr10:81979537 - 81979537(1)	intron_variant; NMD_transcript_variant
rs17726464	chr10:81978490 - 81978490(1)	intron_variant; NMD_transcript_variant
rs7911681	chr10:81982939 - 81982939(1)	intron_variant; NMD_transcript_variant
rs17726679	chr10:81985054 - 81985054(1)	intron_variant; NMD_transcript_variant
rs17648057	chr10:81990762 - 81990762(1)	intron_variant; NMD_transcript_variant
rs17648154	chr10:81994996 - 81994996(1)	intron_variant; NMD_transcript_variant
rs17098797	chr10:81949896 - 81949896(1)	intron_variant; NMD_transcript_variant
rs17098807	chr10:81954743 - 81954743(1)	intron_variant; NMD_transcript_variant
rs17098812	chr10:81954773 - 81954773(1)	intron_variant; NMD_transcript_variant
rs7099000	chr10:81959751 - 81959751(1)	intron_variant; NMD_transcript_variant
rs7101244	chr10:81960673 - 81960673(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.3-23.32	chr10:75900000-92300000	1 (0/1/0)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Gene relationship with MDD

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Region: chr10:81875314..82987179 View in gBrowse