Gene Report

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Basic Info

Approved Symbol	LMAN2L
Symbol Alias	DKFZp564L2423, VIPL
Approved Name	lectin, mannose-binding 2-like
Location	2q11.1
Position	chr2:96705929-96740064, -1
External Links	HGNC: 19263 Entrez Gene: 81562 Ensembl: ENSG00000114988 UCSC: uc002swv.3
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, D. T.,2011	SNP: rs2271893, rs6746896	The results suggest novel association findings near the gene.	Positive	Comment on Study
Lim C.H., 2014	SNP: rs6746896, rs2271893	A positive association between LMAN2L (rs6746896) and risk of both BPD and SZ in a pooled population (P-value=0.009 and 0.001, respectively).	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	TAS[12609988]	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	TAS[12878160]	6
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005537	mannose binding	molecular function	TAS[12609988]	1
GO:0005794	Golgi apparatus	cellular component	IDA[12878160]	60
GO:0006457	protein folding	biological process	NAS[12609988]	7
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0005789	endoplasmic reticulum membrane	cellular component	IDA[12609988]	52
GO:0030134	ER to Golgi transport vesicle	cellular component	NAS[12878160]	1
GO:0015031	protein transport	biological process	IMP[12878160]	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2271893	chr2:96739703 - 96739703(1)	intron_variant; NMD_transcript_variant	3(2/1/0)
rs6746896	chr2:96745212 - 96745212(1)		5(3/0/2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2q11	chr2:93900000-102100000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p11-q14	chr2:83100000-129100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24914473	A positive association between LMAN2L (rs6746896) and risk of both BPD and SZ in a pooled population (P-value= 0.001 and 0.009, respectively).	Positive

Gene relationship with MDD

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Region: chr2:96705929..96740064 View in gBrowse