GO Report

Basic Info

ID	GO:0005887
Name	integral component of plasma membrane
Type	cellular component
No. of Genes in BDgene	158
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
GO: 0005887: integral to plasma membrane	PBA paper	Askland, K.,2009	NIMH	Fisher's exact test	Results given for gene sets with P < 0.01 from the NIMH PBA-CC data

GO related genes in BDgene (count: 158)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
NRXN3	neurexin 3	14q31	2(2/0/0)	TAS[1621094]
NRG3	neuregulin 3	10q23.1	2(0/2/0)	NAS[9275162]
SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	2p15-p13	1(0/1/0)	IC[8910405]
CMKLR1	chemokine-like receptor 1	12q23.3	1(0/1/0)	TAS[9425281]
KCNMB2	potassium channel subfamily M regulatory beta subunit 2	3q26.32	1(1/0/0)	IDA[10692449]
MTNR1A	melatonin receptor 1A	4q35	1(0/1/0)	IDA[10531408]
HLA-A	major histocompatibility complex, class I, A	6p21.3	1(0/1/0)	NAS[6609814]
TSHR	thyroid stimulating hormone receptor	14q24-q31	1(1/0/0)	TAS[8552586]
CTLA4	cytotoxic T-lymphocyte-associated protein 4	2q33	2(1/1/0)	TAS[3220103]
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	4p12	3(2/0/1)	ISS
CHRM1	cholinergic receptor, muscarinic 1	11q12-q13	1(0/1/0)	IEA
NPFFR2	neuropeptide FF receptor 2	4q21	1(0/1/0)	TAS[10079187]
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	7q31.3	1(1/0/0)	TAS[8387522]
ADRB2	adrenoceptor beta 2, surface	5q31-q32	1(1/0/0)	IDA[12297500]
PTGFR	prostaglandin F receptor (FP)	1p31.1	1(1/0/0)	TAS[8300593]
AGTR1	angiotensin II receptor, type 1	3q24	1(1/0/0)	IC[1378723]
GRM7	glutamate receptor, metabotropic 7	3p26-p25	3(2/1/0)	NAS[9473604]
SLC4A11	solute carrier family 4, sodium borate transporter, member 11	20p13	1(0/1/0)	IBA
GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	6q15	1(1/0/0)	TAS[10779366]
SLC6A2	solute carrier family 6 (neurotransmitter transporter), member 2	16q12.2	2(0/2/0)	IEA
SLC14A1	solute carrier family 14 (urea transporter), member 1 (Kidd blood group)	18q11-q12	1(0/1/0)	IDA[19865084]
CCKBR	cholecystokinin B receptor	11p15.4	1(1/0/0)	IC[10913157]
MC5R	melanocortin 5 receptor	18p11.2	1(0/1/0)	TAS[7739752]
ROR1	receptor tyrosine kinase-like orphan receptor 1	1p31.3	1(0/0/1)	TAS[1334494]
GRM4	glutamate receptor, metabotropic 4	6p21.3	2(2/0/0)	IDA[15102938]
TRPM2	transient receptor potential cation channel, subfamily M, member 2	21q22.3	5(3/2/0)	TAS[9806837]
MUC4	mucin 4, cell surface associated	3q29	2(0/2/0)	TAS[10024507]
ADRA2A	adrenoceptor alpha 2A	10q25.2	1(0/1/0)	IDA[10948191]
ROR2	receptor tyrosine kinase-like orphan receptor 2	9q22	1(0/1/0)	TAS[1334494]
NRXN1	neurexin 1	2p16.3	1(1/0/0)	TAS[1621094]
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Xq23	7(4/3/0)	IMP[18703043]
NOTCH4	notch 4	6p21.3	2(0/2/0)	TAS[11823422]
SSTR5	somatostatin receptor 5	16p13.3	2(1/1/0)	TAS[7908405]
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	5q11.2-q13	3(2/1/0)	IDA[22957663]
CHRM3	cholinergic receptor, muscarinic 3	1q43	1(0/1/0)	ISS
ADORA2B	adenosine A2b receptor	17p12	1(1/0/0)	TAS[7558011]
TFRC	transferrin receptor	3q29	1(0/1/0)	TAS[6090955]
TAAR6	trace amine associated receptor 6	6q23.1	5(4/1/0)	IBA
ADCY9	adenylate cyclase 9	16p13.3	2(1/1/0)	TAS[9628827]
HCRTR2	hypocretin (orexin) receptor 2	6p12.1	1(1/0/0)	TAS[9491897]
PLXNA2	plexin A2	1q32.2	1(1/0/0)	ISS
GRM3	glutamate receptor, metabotropic 3	7q21.1-q21.2	7(3/4/0)	IBA
HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	10q21-q24	2(0/2/0)	TAS[8226867]
IL17RA	interleukin 17 receptor A	22q11.1	1(0/1/0)	NAS[9367539]
PTPRO	protein tyrosine phosphatase, receptor type, O	12p13-p12	1(0/1/0)	NAS[7665166]
GRIK4	glutamate receptor, ionotropic, kainate 4	11q23.3	2(1/1/0)	TAS[8263508]
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	4p12	2(2/0/0)	TAS[8719416]
HCAR3	hydroxycarboxylic acid receptor 3	12q24.31	1(0/1/0)	TAS[7505609]
HTR1F	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	3p12	1(1/0/0)	IMP[21422162]
HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	5q31-q33	2(1/1/0)	IEA
EDA2R	ectodysplasin A2 receptor	Xq11.1	1(0/0/1)	IEA
EPHA5	EPH receptor A5	4q13.1	1(1/0/0)	IEA
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	21q22.3	1(0/1/0)	IC[11500512]
AVPR1B	arginine vasopressin receptor 1B	1q32	4(3/1/0)	TAS[7805841]
ABCC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	16q12	1(0/0/1)	IDA[16359813]
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	15q12	3(1/2/0)	IMP[22303015]
SLC17A3	solute carrier family 17 (organic anion transporter), member 3	6p22.2	1(1/0/0)	IDA[20810651]
AQP8	aquaporin 8	16p12	1(0/0/1)	TAS[9806845]
GRIK2	glutamate receptor, ionotropic, kainate 2	6q16.3	3(1/1/1)	TAS[7536611]
DRD5	dopamine receptor D5	4p16.1	2(0/2/0)	NAS[1826762]; TAS[9457173]
TRHR	thyrotropin-releasing hormone receptor	8q23.1	1(0/1/0)	TAS[8395824]
PLA2R1	phospholipase A2 receptor 1, 180kDa	2q23-q24	1(1/0/0)	NAS[7721806]
OR5AS1	olfactory receptor, family 5, subfamily AS, member 1	11q11	1(0/0/1)	IBA
DRD2	dopamine receptor D2	11q22-q23	28(8/20/0)	IC[2531656]; IDA[8413587]
TAAR1	trace amine associated receptor 1	6q23.1	1(0/1/0)	IBA
P2RX4	purinergic receptor P2X, ligand gated ion channel, 4	12q24.32	1(0/1/0)	IC[11606481]; IMP[10515189]
ADRA1B	adrenoceptor alpha 1B	5q33.3	1(1/0/0)	TAS[1328250]
FAM26F	family with sequence similarity 26, member F	6q22.1	1(1/0/0)	IBA
SLC15A1	solute carrier family 15 (oligopeptide transporter), member 1	13q32.3	1(0/1/0)	TAS[7896779]
CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	15q24	2(1/1/0)	IC[11742001]
ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	12q24.11	2(0/2/0)	TAS[2844796]
MARCO	macrophage receptor with collagenous structure	2q14.2	1(0/1/0)	TAS[9468508]
HLA-B	major histocompatibility complex, class I, B	6p21.3	2(0/1/1)	NAS[518865]
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	17p13.1	1(1/0/0)	TAS[1976629]
ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	7p12.3	2(2/0/0)	IBA
MCHR1	melanin-concentrating hormone receptor 1	22q13.3	2(1/1/0)	TAS[10421367]
PTPRN2	protein tyrosine phosphatase, receptor type, N polypeptide 2	7q36	1(0/0/1)	TAS[8798755]
CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	17p13.1	1(1/0/0)	NAS[8872460]
DSCAM	Down syndrome cell adhesion molecule	21q22.2-q22.3	3(1/2/0)	TAS[9426258]
GPR50	G protein-coupled receptor 50	Xq28	3(2/1/0)	TAS[8647286]
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	9q34.3	3(2/1/0)	IDA[7685113]
DRD3	dopamine receptor D3	3q13.3	19(4/15/0)	IC[8301582]; IDA[8413587]
GJA8	gap junction protein, alpha 8, 50kDa	1q21.1	1(1/0/0)	TAS[7796604]
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	3(1/1/1)	IDA[15494731]
ADRA1A	adrenoceptor alpha 1A	8p21.2	2(0/2/0)	TAS[8396931]
CD36	CD36 molecule (thrombospondin receptor)	7q11.2	3(2/1/0)	TAS[9568716]
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	5q34	2(1/1/0)	ISS
NRG1	neuregulin 1	8p12	15(10/5/0)	IEA
BDKRB1	bradykinin receptor B1	14q32.1-q32.2	1(1/0/0)	TAS[8063797]
TNF	tumor necrosis factor	6p21.3	4(2/2/0)	IDA[18355445]
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	16p13.2	1(1/0/0)	TAS[8768735]
GRIK3	glutamate receptor, ionotropic, kainate 3	1p34.3	1(1/0/0)	IDA[7719709]
DRD4	dopamine receptor D4	11p15.5	13(1/12/0)	IDA[15755724]
SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	9p24	1(1/0/0)	TAS[7521911]
SSTR1	somatostatin receptor 1	14q13	1(1/0/0)	TAS[1346068]
BDKRB2	bradykinin receptor B2	14q32.1-q32.2	1(1/0/0)	TAS[7916737]
STEAP3	STEAP family member 3, metalloreductase	2q14.2	1(0/0/1)	IBA
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	15q12	6(6/0/0)	TAS[1321750]
NUMB	numb homolog (Drosophila)	14q24.3	1(0/0/1)	TAS[7596406]
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	4p16.1	1(0/0/1)	IEA
TACR1	tachykinin receptor 1	2p13.1-p12	3(3/0/0)	TAS[1657150]
CHRM5	cholinergic receptor, muscarinic 5	15q26	1(0/1/0)	IEA
NTSR2	neurotensin receptor 2	2p25.1	1(1/0/0)	TAS[9851594]
SIGLEC6	sialic acid binding Ig-like lectin 6	19q13.3	1(1/0/0)	TAS[9465907]
GJA5	gap junction protein, alpha 5, 40kDa	1q21.2	1(1/0/0)	IDA[22247482]
TENM2	teneurin transmembrane protein 2	5q35	1(0/0/1)	IEA
GJA1	gap junction protein, alpha 1, 43kDa	6q22.31	1(1/0/0)	TAS[15709751]
SLC6A3	solute carrier family 6 (neurotransmitter transporter), member 3	5p15.3	11(5/6/0)	IEA
VIPR2	vasoactive intestinal peptide receptor 2	7q36.3	1(1/0/0)	TAS[7811244]
HCRTR1	hypocretin (orexin) receptor 1	1p33	1(1/0/0)	TAS[9491897]
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	13q14-q21	22(7/15/0)	IEA
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	22q12.3	2(1/1/0)	NAS[1702217]
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	4(2/2/0)	TAS[10598591]
SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	17q11.2	44(18/26/0)	IC[19270731]
HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11q23.1	2(1/1/0)	IEA
MMP16	matrix metallopeptidase 16 (membrane-inserted)	8q21	1(0/1/0)	TAS[7559440]
CNR2	cannabinoid receptor 2 (macrophage)	1p	1(1/0/0)	TAS[8679694]
PTPRD	protein tyrosine phosphatase, receptor type, D	9p24.1-p23	1(0/0/1)	TAS[7896816]
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11q23.1-q23.2	2(1/1/0)	TAS[7565620]
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	5q34	1(1/0/0)	ISS
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	9q22.1-q22.3	2(0/2/0)	IDA[9872316]
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	12p13.1	8(4/4/0)	TAS[8768735]
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	Xq28	3(1/2/0)	TAS[8391122]
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	5q34	1(0/1/0)	TAS[8632757]
HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	7q36.1	2(1/1/0)	IEA
SLC18A2	solute carrier family 18 (vesicular monoamine transporter), member 2	10q25	1(1/0/0)	TAS[8095030]
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	6q14-q15	1(0/1/0)	IMP[21422162]
CHRM2	cholinergic receptor, muscarinic 2	7q35-q36	1(0/1/0)	IDA[24256733]
HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	1p36-p35	3(1/2/0)	TAS[8522988]
GRM2	glutamate receptor, metabotropic 2	3p21.2	1(0/1/0)	IBA
CACNB2	calcium channel, voltage-dependent, beta 2 subunit	10p12	3(2/1/0)	NAS[9594024]
IL2RB	interleukin 2 receptor, beta	22q13	2(1/1/0)	TAS[8514792]
GPC5	glypican 5	13q32	1(0/0/1)	TAS[7657705]
P2RX7	purinergic receptor P2X, ligand gated ion channel, 7	12q24	9(2/7/0)	IC[9038151]
KCNK10	potassium channel, two pore domain subfamily K, member 10	14q31	1(1/0/0)	IBA
TAAR8	trace amine associated receptor 8	6q23.2	1(0/1/0)	IBA
TENM4	teneurin transmembrane protein 4	11q13	6(4/2/0)	IEA
KCND2	potassium channel, voltage gated Shal related subfamily D, member 2	7q31	1(1/0/0)	IDA[24811166]
SLC20A1	solute carrier family 20 (phosphate transporter), member 1	2q13	1(0/1/0)	TAS[8041748]
CHRM4	cholinergic receptor, muscarinic 4	11p12-p11.2	1(0/1/0)	IEA
CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	4p14	2(0/2/0)	IDA[25282151]
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	15q24-q25	2(2/0/0)	IEA
GPR87	G protein-coupled receptor 87	3q24	1(1/0/0)	IBA
TLR4	toll-like receptor 4	9q33.1	1(1/0/0)	IDA[15027902]
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	3q24	1(1/0/0)	IBA
OXTR	oxytocin receptor	3p25	1(0/1/0)	TAS[10858434]
DRD1	dopamine receptor D1	5q34-q35	11(6/5/0)	IBA; IC[2144334]
CNR1	cannabinoid receptor 1 (brain)	6q14-q15	5(0/5/0)	TAS[1718258]
ADRA2C	adrenoceptor alpha 2C	4p16.3	1(0/1/0)	IDA[16605244]
CRHR2	corticotropin releasing hormone receptor 2	7p14.3	3(2/1/0)	TAS[8536644]
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	1p36.3-p34.3	1(0/1/0)	IDA[1652050]
FGFR2	fibroblast growth factor receptor 2	10q25.3-q26	2(1/1/0)	IDA[15629145]
SYPL1	synaptophysin-like 1	7q22.2	1(1/0/0)	TAS[8034131]
GLRA1	glycine receptor, alpha 1	5q33.1	1(1/0/0)	IDA[7506679]; IMP[11973623]; NAS[2155780]
TM9SF2	transmembrane 9 superfamily member 2	13q32.2	1(0/0/1)	TAS[9729438]
KCNH7	potassium channel, voltage gated eag related subfamily H, member 7	2q24.3	3(2/0/1)	IBA
SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	15q13	1(1/0/0)	IEA
ANK2	ankyrin 2, neuronal	4q25-q26	1(0/1/0)	IEA