Gene Report

Basic Info
Approved Symbol CREM
Symbol Alias hCREM-2
Approved Name cAMP responsive element modulator
Location 10p12.1-p11.1
Position chr10:35126791-35212958, 1
External Links HGNC: 2352
Entrez Gene: 1390
Ensembl: ENSG00000095794
UCSC: uc001iyb.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Crisafulli, C.,2012 SNP: rs1148247, rs12775799, rs16935888, rs4934735, rs6481941 We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 5)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Related other genetic factors
Gene related SNPs (count: 37)

Literature-origin SNPs (count: 5)

LD-proxies (count: 32)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr10:35126791..35212958 View in gBrowse
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