Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CREM
Symbol Alias	hCREM-2
Approved Name	cAMP responsive element modulator
Location	10p12.1-p11.1
Position	chr10:35126791-35212958, 1
External Links	HGNC: 2352 Entrez Gene: 1390 Ensembl: ENSG00000095794 UCSC: uc001iyb.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Crisafulli, C.,2012	SNP: rs1148247, rs12775799, rs16935888, rs4934735, rs6481941	We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	NAS[8206879]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66
GO:0007275	multicellular organismal development	biological process	IEA	24
GO:0030154	cell differentiation	biological process	IEA	31
GO:0003677	DNA binding	molecular function	NAS[7916662]	83

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IEA	43
GO:0051591	response to cAMP	biological process	IEA	4
GO:0006687	glycosphingolipid metabolic process	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[10373550]	563
GO:0008140	cAMP response element binding protein binding	molecular function	NAS[8206879]	1
GO:0007165	signal transduction	biological process	TAS[7916662]	136
GO:0005667	transcription factor complex	cellular component	IEA	18
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[8206879]; NAS[7916662]	62
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IEA	10
GO:0032922	circadian regulation of gene expression	biological process	IEA	22
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
cremPathway	Regulation of Spermatogenesis by CREM	2
dreampathway	Repression of Pain Sensation by the Transcriptional Regulator DREAM	4

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CREM	CSNK1A1	NO	in vitro;in vivo	8404858
CREM	CSNK2A1	YES	in vitro;in vivo	8404858
CREM	FHL5	NO	in vitro;in vivo;yeast 2-hybrid	10086359
CREM	CAMK2G	NO	in vitro;in vivo	8404858
CREM	CDK1	NO	in vitro;in vivo	8404858
CREM	ATF1	NO	in vitro	12805554
CREM	PRKCA	NO	in vitro;in vivo	8404858
CREM	CDC34	NO	in vivo;yeast 2-hybrid	10373550
CREM	SPI1	NO	in vitro	7730336
CREM	GSK3A	NO	in vitro;in vivo	8404858
CREM	CREB3L1	NO	in vitro	12805554
CREM	TBP	YES	in vitro	10409662
CREM	PRKACA	NO	in vitro;in vivo	8404858
CREM	CSNK2A2	NO	in vitro;in vivo	8404858
CREM	KCNIP3	NO	in vitro	11094064 , 12198160
CREM	CAMK2D	NO	in vitro;in vivo	8404858
CREM	CREB1	YES	in vitro;in vivo	7809053
CREM	TAF4	NO	in vitro	10409662

Related other genetic factors

Gene related SNPs (count: 37)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4934735	chr10:35207802 - 35207802(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1148247	chr10:35208018 - 35208018(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs12775799	chr10:35199336 - 35199336(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs6481941	chr10:35151213 - 35151213(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs16935888	chr10:35143477 - 35143477(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 32)

rs_ID	Location	Functional Annotation
rs17591857	chr10:35210115 - 35210115(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs17591781	chr10:35209610 - 35209610(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4934736	chr10:35207940 - 35207940(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2384352	chr10:35203904 - 35203904(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs11010125	chr10:35214025 - 35214025(1)	downstream_gene_variant
rs3740082	chr10:35213605 - 35213605(1)	downstream_gene_variant
rs10827492	chr10:35140897 - 35140897(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1213392	chr10:35141357 - 35141357(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4934734	chr10:35145445 - 35145445(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs12761675	chr10:35149409 - 35149409(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1531550	chr10:35175850 - 35175850(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; splice_region_variant; upstream_gene_variant
rs4934537	chr10:35152584 - 35152584(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs16935902	chr10:35177843 - 35177843(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs1545757	chr10:35156660 - 35156660(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16935910	chr10:35204050 - 35204050(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs10827493	chr10:35166048 - 35166048(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2295415	chr10:35212510 - 35212510(1)	3_prime_UTR_variant; downstream_gene_variant
rs10508816	chr10:35171048 - 35171048(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs17591135	chr10:35176262 - 35176262(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs12769484	chr10:35176818 - 35176818(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4934538	chr10:35183222 - 35183222(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4934539	chr10:35183271 - 35183271(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2505639	chr10:35185493 - 35185493(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4934540	chr10:35185771 - 35185771(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7077242	chr10:35193037 - 35193037(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs1057108	chr10:35196021 - 35196021(1)	5_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16915805	chr10:35137282 - 35137282(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16915801	chr10:35135210 - 35135210(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs7913615	chr10:35134029 - 35134029(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4934730	chr10:35126627 - 35126627(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs10827491	chr10:35138467 - 35138467(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs17499247	chr10:35137827 - 35137827(1)	5_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
10p11-p14	chr10:6600000-39800000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
22386572	We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that 14 SNPs under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr10:35126791..35212958 View in gBrowse