Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	RC3H1
Symbol Alias	KIAA2025, roquin, RP5-1198E17.5, RNF198
Approved Name	ring finger and CCCH-type domains 1
Previous Name	ring finger and CCCH-type zinc finger domains 1
Name Alias	KIAA2025 protein
Location	1q25.1
Position	chr1:173931214-174022297, -1
External Links	HGNC: 29434 Entrez Gene: 149041 Ensembl: ENSG00000135870 UCSC: uc001gju.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10798301	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003730	mRNA 3'-UTR binding	molecular function	ISS	4

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010494	cytoplasmic stress granule	cellular component	ISS	2
GO:0010608	posttranscriptional regulation of gene expression	biological process	ISS	3
GO:0042098	T cell proliferation	biological process	IEA	5
GO:0030889	negative regulation of B cell proliferation	biological process	ISS	5
GO:0033962	cytoplasmic mRNA processing body assembly	biological process	ISS	2
GO:0002634	regulation of germinal center formation	biological process	ISS	1
GO:0000932	cytoplasmic mRNA processing body	cellular component	ISS	3
GO:0048535	lymph node development	biological process	IEA	1
GO:0050856	regulation of T cell receptor signaling pathway	biological process	ISS	1
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:1901224	positive regulation of NIK/NF-kappaB signaling	biological process	IEA	1
GO:0016567	protein ubiquitination	biological process	TAS[19217324]	18
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0002635	negative regulation of germinal center formation	biological process	ISS	1
GO:0001782	B cell homeostasis	biological process	IEA	3
GO:0045623	negative regulation of T-helper cell differentiation	biological process	ISS	1
GO:0061630	ubiquitin protein ligase activity	molecular function	TAS[19217324]	2
GO:0000956	nuclear-transcribed mRNA catabolic process	biological process	ISS	1
GO:0048536	spleen development	biological process	IEA	4
GO:0046007	negative regulation of activated T cell proliferation	biological process	ISS	1
GO:0043488	regulation of mRNA stability	biological process	ISS	1
GO:0061470	T follicular helper cell differentiation	biological process	IEA	1
GO:0043029	T cell homeostasis	biological process	IEA	5