Gene Report

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Basic Info

Approved Symbol	THSD7B
Symbol Alias	KIAA1679
Approved Name	thrombospondin, type I, domain containing 7B
Location	2q22.1
Position	chr2:136765545-137677717, 1
External Links	HGNC: 29348 Entrez Gene: 80731 Ensembl: ENSG00000144229 UCSC: uc002tva.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs718632	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs718632	chr2:137345235 - 137345235(1)	intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs4594503	chr2:137358861 - 137358861(1)	intron_variant
rs7355522	chr2:137372056 - 137372056(1)	intron_variant
rs12474855	chr2:137346151 - 137346151(1)	intron_variant
rs1453294	chr2:137358724 - 137358724(1)	intron_variant
rs1349751	chr2:137352489 - 137352489(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q22.1-q23.3	chr2:136100000-154000000	1 (0/1/0)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
2q12.3-q22.1	chr2:106700000-141500000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:136765545..137677717 View in gBrowse