Gene Report

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Basic Info

Approved Symbol	NAALAD2
Symbol Alias	NAALADASE2, NAADALASE2, GPCIII
Approved Name	N-acetylated alpha-linked acidic dipeptidase 2
Name Alias	glutamate carboxypeptidase III
Location	11q14.3-q21
Position	chr11:90131515-90192894, 1
External Links	HGNC: 14526 Entrez Gene: 10003 Ensembl: ENSG00000077616 UCSC: uc001pdf.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs4268468	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	NAS[10085079]	219
GO:0008239	dipeptidyl-peptidase activity	molecular function	NAS[10085079]	3
GO:0008237	metallopeptidase activity	molecular function	IEA	8

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006508	proteolysis	biological process	NAS[10085079]	34
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0004180	carboxypeptidase activity	molecular function	NAS[10085079]	3
GO:0008236	serine-type peptidase activity	molecular function	NAS[10085079]	9
GO:0016805	dipeptidase activity	molecular function	NAS[10085079]	1
GO:0050129	N-formylglutamate deformylase activity	molecular function	IEA	1
GO:0042135	neurotransmitter catabolic process	biological process	IEA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4268468	chr11:90153116 - 90153116(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs4393275		chr11:90153229 - 90153229(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
11q14.1-14.3	chr11:77400000-93000000	1 (0/1/0)
11q14-q21	chr11:77100000-92800000	1 (0/1/0)
11q14.3	chr11:88600000-93000000	1 (0/0/1)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:90131515..90192894 View in gBrowse