Gene Report

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Basic Info

Approved Symbol	IL15RA
Symbol Alias	CD215, IL-15RA
Approved Name	interleukin 15 receptor, alpha
Location	10p15.1
Position	chr10:5943639-5978187, -1
External Links	HGNC: 5978 Entrez Gene: 3601 Ensembl: ENSG00000134470 UCSC: uc021pmo.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0042. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0004871	signal transducer activity	molecular function	TAS[7641685]	32

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IEA	85
GO:0005515	protein binding	molecular function	IPI[16284400]	563
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS[7641685]	23
GO:0004896	cytokine receptor activity	molecular function	TAS[7641685]	2
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0007165	signal transduction	biological process	TAS[8530383]	136
GO:0008283	cell proliferation	biological process	TAS[8530383]	37
GO:0031965	nuclear membrane	cellular component	IEA	15
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	52

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	17
hsa04630	Jak-STAT signaling pathway	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IL15RA	AXL	NO	in vitro;in vivo	16308569
IL15RA	IL2RG	NO	in vitro;in vivo	11418623 , 7641685
IL15RA	SYK	NO	in vitro	11714793
IL15RA	TRAF2	NO	in vivo	11064452
IL15RA	IL2RB	YES	in vitro;in vivo	7641685
IL15RA	IL15	NO	in vitro;in vivo	7641685 , 16284400

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10p13-p15	chr10:0-17300000	1 (0/1/0)
10p15	chr10:0-6600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:5943639..5978187 View in gBrowse