Gene Report
Basic Info
Approved Symbol |
JAK1
|
Previous Symbol |
JAK1B |
Symbol Alias |
JAK1A, JTK3 |
Approved Name |
Janus kinase 1 |
Location |
1p32.3-p31.3 |
Position |
chr1:64833229-64966504, -1 |
External Links |
HGNC: 6190
Entrez Gene: 3716
Ensembl: ENSG00000162434
UCSC: uc001dbu.1
|
No. of Studies |
1 (Positive: 0; Negative: 1; trend: 0)
|
Overlap with SZ? |
NO
|
Overlap with MDD? |
NO
|
Gene related studies (count: 1)
Gene functional annotation
Gene related GO terms (count: 29)
Gene related KEGG pathways (count: 3)
KEGG pathways by PBA (count: 1)
KEGG pathways by database search (count: 2)
Gene related BioCarta pathways (count: 12)
BioCarta pathways by PBA (count: 0)
BioCarta pathways by database search (count: 12)
Gene related interactors from protein-protein interactions data in HPRD (count: 62)
Gene |
Interactor |
Interactor in BDgene? |
Experiment Type |
PMID |
JAK1 |
PTPN2
|
NO
|
in vitro;in vivo |
11909529
,
15588985
|
JAK1 |
SH2B2
|
NO
|
in vivo |
11751854
|
JAK1 |
CSF3R
|
NO
|
in vitro;in vivo |
7512720
|
JAK1 |
INSR
|
NO
|
in vitro;in vivo |
12456798
,
9492017
|
JAK1 |
PDGFRA
|
NO
|
in vitro |
11468294
|
JAK1 |
STAT6
|
NO
|
in vitro |
10856136
|
JAK1 |
IL4R
|
NO
|
in vitro;in vivo |
12133952
|
JAK1 |
IL7R
|
NO
|
in vivo |
8647212
,
15996891
|
JAK1 |
ELP2
|
NO
|
in vivo |
10954736
|
JAK1 |
IFNAR2
|
NO
|
in vivo |
12133952
|
JAK1 |
EIF2AK2
|
NO
|
in vivo |
17290288
|
JAK1 |
IL2RG
|
NO
|
in vivo |
7973658
|
JAK1 |
STAT5A
|
NO
|
in vivo |
11722592
|
JAK1 |
TNFRSF1A
|
NO
|
in vitro;in vivo |
11801527
|
JAK1 |
IRS2
|
NO
|
in vivo |
7499365
|
JAK1 |
PDGFRB
|
YES
|
in vitro;in vivo |
8657151
,
9484840
|
JAK1 |
FES
|
NO
|
in vivo |
11160325
|
JAK1 |
BRCA1
|
NO
|
in vivo |
11163768
|
JAK1 |
SYK
|
NO
|
in vitro |
10825200
|
JAK1 |
IRS1
|
NO
|
in vitro;in vivo |
11162588
|
JAK1 |
SHB
|
NO
|
in vivo |
12200137
|
JAK1 |
OSMR
|
NO
|
in vivo |
10586060
|
JAK1 |
RAF1
|
NO
|
in vivo |
9446616
|
JAK1 |
JAKMIP1
|
NO
|
in vitro;in vivo |
15277531
|
JAK1 |
FER
|
NO
|
in vitro |
12738762
|
JAK1 |
CCR1
|
NO
|
in vivo |
14674010
|
JAK1 |
CXCR4
|
NO
|
in vivo |
12163560
|
JAK1 |
PTPRC
|
YES
|
in vitro |
11201744
|
JAK1 |
IL3RA
|
NO
|
in vivo |
15988755
|
JAK1 |
IL6ST
|
NO
|
in vitro;in vivo |
11468294
,
11742534
|
JAK1 |
GRB2
|
NO
|
in vivo |
11527382
,
8536716
|
JAK1 |
PTPN11
|
NO
|
in vivo |
8995399
,
12403768
,
11036942
|
JAK1 |
CCR5
|
NO
|
in vivo |
10037796
|
JAK1 |
INPP5D
|
NO
|
in vivo |
10875931
|
JAK1 |
GNB2L1
|
NO
|
in vitro;in vivo |
12960323
|
JAK1 |
STAT2
|
NO
|
in vitro;in vivo |
9020188
|
JAK1 |
TYK2
|
NO
|
in vitro;in vivo |
7589562
,
8702790
|
JAK1 |
JAK3
|
NO
|
in vitro;in vivo |
9553136
,
12559972
|
JAK1 |
GHR
|
NO
|
in vitro;in vivo |
10502458
|
JAK1 |
PLA2G4A
|
NO
|
in vivo |
8612580
|
JAK1 |
IL10RA
|
NO
|
in vitro;in vivo |
12133952
,
12374810
,
10433356
|
JAK1 |
MDK
|
YES
|
in vitro |
9452495
|
JAK1 |
IL2RB
|
YES
|
in vivo |
7973659
,
12133952
,
8700888
|
JAK1 |
ABL1
|
NO
|
in vivo |
12130510
|
JAK1 |
IL9R
|
NO
|
in vitro;in vivo |
8756628
|
JAK1 |
STAM
|
NO
|
in vivo |
9133424
|
JAK1 |
IL21R
|
NO
|
in vivo |
11016959
,
11418623
|
JAK1 |
SOCS1
|
NO
|
in vitro |
11133764
|
JAK1 |
STAT1
|
NO
|
in vitro;in vivo |
11722592
,
7657660
,
11294897
,
10918587
,
15322115
,
7543024
,
11839738
,
12817007
,
7690989
,
12637327
,
10982844
|
JAK1 |
IGF1R
|
NO
|
in vitro;in vivo |
9492017
|
JAK1 |
CSF2RB
|
YES
|
in vivo |
11557047
|
JAK1 |
PTPN6
|
NO
|
in vitro |
7629131
,
9520455
|
JAK1 |
STAM2
|
NO
|
in vitro |
10899310
,
10993906
|
JAK1 |
PRMT5
|
NO
|
in vitro |
10531356
|
JAK1 |
STAT3
|
NO
|
in vitro;in vivo |
11722592
,
11940572
,
11294897
,
10918587
,
12244095
,
11350938
,
12626508
,
8626374
,
12576423
,
14551213
,
8272872
,
9566874
|
JAK1 |
IL5RA
|
NO
|
in vitro |
9516124
|
JAK1 |
PTK2B
|
YES
|
in vitro;in vivo |
10702271
|
JAK1 |
IFNGR1
|
NO
|
in vivo |
12133952
|
JAK1 |
PLAUR
|
NO
|
in vitro;in vivo |
9417082
|
JAK1 |
BTK
|
NO
|
in vivo |
9178903
|
JAK1 |
TEC
|
NO
|
in vivo |
9178903
|
JAK1 |
SOCS3
|
NO
|
in vivo |
10707961
|
Related other genetic factors
Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
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