Gene Report

Basic Info
Approved Symbol PIK3C3
Symbol Alias Vps34
Approved Name phosphatidylinositol 3-kinase, catalytic subunit type 3
Previous Name phosphoinositide-3-kinase, class 3
Location 18q12.3
Position chr18:41955206-42087830, 1
External Links HGNC: 8974
Entrez Gene: 5289
Ensembl: ENSG00000078142
UCSC: uc002lap.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Stopkova, P., 2004 (a) Other variant: PIK3C3_-432C->T, PIK3C3_promoter_-86insC A promoter mutation in a PI regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 32)

GO terms by PBA (count: 5)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 7)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

View in gBrowse

Region: chr18:41955206..42087830 View in gBrowse
View in gBrowse