Gene Report

Basic Info
Approved Symbol PRKAR1A
Previous Symbol PRKAR1, TSE1
Symbol Alias CNC1
Approved Name protein kinase, cAMP-dependent, regulatory, type I, alpha
Previous Name tissue specific extinguisher 1
Name Alias Carney complex type 1
Location 17q24.2
Position chr17:68511780-68551319, 1
External Links HGNC: 9388
Entrez Gene: 5573
Ensembl: ENSG00000108946
UCSC: uc002jhg.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Forero, D. A., 2016 SNP: rs4968898 P-value=0.03. HapMap based haplotype block analysis as well as sliding window haplotype analysis revealed significant associations with NF1 (p=0,01), PPP3CB (p=0005) and PRKAR1A (p=0,03) in the total BP and SZ samples. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 37)

GO terms by PBA (count: 3)

GO terms by database search (count: 34)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 20)

BioCarta pathways by PBA (count: 1)

BioCarta pathways by database search (count: 19)

Gene related interactors from protein-protein interactions data in HPRD (count: 22)

Related other genetic factors
Gene related SNPs (count: 3)

Literature-origin SNPs (count: 1)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr17:68511780..68551319 View in gBrowse
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