BDgene

Gene Report

Basic Info
Approved Symbol YWHAE
Symbol Alias FLJ45465
Approved Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Previous Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Name Alias 14-3-3 epsilon
Location 17p13.3
Position chr17:1344272-1400378, -1
External Links HGNC: 12851
Entrez Gene: 7531
Ensembl: ENSG00000108953
UCSC: uc002fsj.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Liu, J,2011(b) SNP: rs11655548, rs12452627, rs1532976, rs1873827, rs2131431, rs28365859, rs34041110, rs3752826, rs7224258, rs7225165, rs8064578 Considering the size of our sample sets (power > 90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 46)

GO terms by PBA (count: 2)

GO terms by database search (count: 44)


Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)


Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 64)

Related other genetic factors
Gene related SNPs (count: 33)

Literature-origin SNPs (count: 11)

LD-proxies (count: 22)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)


Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)


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Region: chr17:1344272..1400378 View in gBrowse
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