Gene Report

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Basic Info

Approved Symbol	CDH7
Approved Name	cadherin 7, type 2
Location	18q22.1
Position	chr18:65750252-65890341, 1
External Links	HGNC: 1766 Entrez Gene: 1005 Ensembl: ENSG00000081138 UCSC: uc002ljz.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P., 2008	SNP: rs12970791, rs1444067, rs2658046, rs2850699, rs2850700, rs4455070	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005509	calcium ion binding	molecular function	IEA	50

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034332	adherens junction organization	biological process	TAS	6
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	IEA	7
GO:0016337	single organismal cell-cell adhesion	biological process	NAS[10861224]	10
GO:0034329	cell junction assembly	biological process	TAS	8
GO:0045216	cell-cell junction organization	biological process	TAS	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CDH7	CDH9	NO	in vivo	10861224
CDH7	CTNNB1	NO	in vivo	10861224
CDH7	CDH12	NO	in vivo	10861224
CDH7	CDH6	NO	in vivo	10861224

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1444067	chr18:65503450 - 65503450(1)		1(0/0/1)
rs2658046	chr18:65454994 - 65454994(1)		1(0/1/0)
rs2850699	chr18:65450257 - 65450257(1)	downstream_gene_variant	1(0/1/0)
rs4455070	chr18:65487125 - 65487125(1)		1(0/1/0)
rs2850700	chr18:65450406 - 65450406(1)	downstream_gene_variant	1(0/1/0)
rs12970791	chr18:65498567 - 65498567(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 7)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18q	chr18:18500000-80373285	1 (0/1/0)
18q12.3-q22.1	chr18:39500000-69100000	1 (0/1/0)
18q21-23	chr18:45900000-80373285	1 (1/0/0)
18q21-q22	chr18:45900000-75400000	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)
18q22	chr18:63900000-75400000	3 (1/1/1)
18q22.1	chr18:63900000-69100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:65750252..65890341 View in gBrowse