Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	SNTG2
Symbol Alias	SYN5, G2SYN
Approved Name	syntrophin, gamma 2
Location	2p25
Position	chr2:950868-1367613, 1
External Links	HGNC: 13741 Entrez Gene: 54221 Ensembl: ENSG00000172554 UCSC: uc002qwq.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs28505970	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003779	actin binding	molecular function	IEA	24
GO:0030165	PDZ domain binding	molecular function	IPI[17292328]	16
GO:0007417	central nervous system development	biological process	TAS[10747910]	21

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016013	syntrophin complex	cellular component	TAS[10747910]	1
GO:0042383	sarcolemma	cellular component	IEA	12
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SNTG2	DTNA	NO	in vitro;in vivo;yeast 2-hybrid	10747910
SNTG2	DMD	NO	in vitro;in vivo;yeast 2-hybrid	10747910
SNTG2	SCN5A	NO	in vitro;in vivo;yeast 2-hybrid	12429735
SNTG2	DTNB	NO	in vitro;in vivo;yeast 2-hybrid	10747910

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs28505970	chr2:1173095 - 1173095(1)	intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p25.3-p25.1	chr2:0-12000000	1 (1/0/0)
2p25.3-25.1	chr2:0-12000000	1 (0/1/0)
2p25	chr2:0-12000000	3 (0/1/2)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q13-q14_126.907cM	chr2:0-4500000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:950868..1367613 View in gBrowse