Gene Report

Basic Info
Approved Symbol EGFR
Previous Symbol ERBB
Symbol Alias ERBB1
Approved Name epidermal growth factor receptor
Previous Name epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Name Alias erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian), "erb-b2 receptor tyrosine kinase 1"
Location 7p12
Position chr7:55019021-55211628, 1
External Links HGNC: 3236
Entrez Gene: 1956
Ensembl: ENSG00000146648
UCSC: uc003tqk.3
No. of Studies 1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sklar, P., 2008 SNP: rs17172438, rs729969 Haplotype analysis further supported single SNP results highlighting EGFR (P-value = 8.36E-08) Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 120)

GO terms by PBA (count: 10)

GO terms by database search (count: 110)

Gene related KEGG pathways (count: 18)

Gene related BioCarta pathways (count: 15)

Gene related interactors from protein-protein interactions data in HPRD (count: 155)

Related other genetic factors
Gene related SNPs (count: 18)

Literature-origin SNPs (count: 2)

LD-proxies (count: 16)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr7:55019021..55211628 View in gBrowse
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