Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	EGFR
Previous Symbol	ERBB
Symbol Alias	ERBB1
Approved Name	epidermal growth factor receptor
Previous Name	epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
Name Alias	erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian), "erb-b2 receptor tyrosine kinase 1"
Location	7p12
Position	chr7:55019021-55211628, 1
External Links	HGNC: 3236 Entrez Gene: 1956 Ensembl: ENSG00000146648 UCSC: uc003tqk.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Sklar, P., 2008	SNP: rs17172438, rs729969	Haplotype analysis further supported single SNP results highlighting EGFR (P-value = 8.36E-08)	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 120)

GO terms by PBA (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051015	actin filament binding	molecular function	IDA[14702346]	9
GO:0045087	innate immune response	biological process	TAS	49
GO:0004714	transmembrane receptor protein tyrosine kinase activity	molecular function	TAS	5
GO:0016020	membrane	cellular component	IDA[12435727]	137
GO:0004716	receptor signaling protein tyrosine kinase activity	molecular function	IEA	2
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005634	nucleus	cellular component	IDA[12828935]	283
GO:0007411	axon guidance	biological process	TAS	60
GO:0005886	plasma membrane	cellular component	IDA; TAS	360
GO:0043235	receptor complex	cellular component	IDA[23382219]	20

GO terms by database search (count: 110)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006412	translation	biological process	IEA	4
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	biological process	IMP[12435727]	2
GO:0004888	transmembrane signaling receptor activity	molecular function	IDA[7736574]	10
GO:0010960	magnesium ion homeostasis	biological process	IEA	3
GO:0071549	cellular response to dexamethasone stimulus	biological process	IEA	4
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	IDA[12435727]; TAS	22
GO:0009986	cell surface	cellular component	IEA	40
GO:0003690	double-stranded DNA binding	molecular function	NAS[6325948]	4
GO:0004709	MAP kinase kinase kinase activity	molecular function	NAS[15542601]	2
GO:0042802	identical protein binding	molecular function	IPI[16777603]	44
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[23418353]	25
GO:0050729	positive regulation of inflammatory response	biological process	IEA	6
GO:0016101	diterpenoid metabolic process	biological process	IEA	2
GO:0019901	protein kinase binding	molecular function	IEA	29
GO:0007435	salivary gland morphogenesis	biological process	IEA	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[20551055]	14
GO:0045740	positive regulation of DNA replication	biological process	IDA[17115032]	7
GO:0045121	membrane raft	cellular component	IDA[12009895]	22
GO:0005615	extracellular space	cellular component	NAS[9103388]	85
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0051592	response to calcium ion	biological process	IEA	7
GO:0005006	epidermal growth factor-activated receptor activity	molecular function	IDA[12435727]; NAS[2790960]	1
GO:0046777	protein autophosphorylation	biological process	IMP[18070883]	16
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	biological process	TAS[12435727]	2
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	IDA[17115032]; IEA; IMP[14702346]; TAS[16076471]	12
GO:0021795	cerebral cortex cell migration	biological process	IEA	2
GO:0042177	negative regulation of protein catabolic process	biological process	IDA[17115032]	5
GO:0030235	nitric-oxide synthase regulator activity	molecular function	IDA[12828935]	4
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	19
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IEA	11
GO:0033590	response to cobalamin	biological process	IEA	1
GO:0045930	negative regulation of mitotic cell cycle	biological process	IEA	2
GO:0048146	positive regulation of fibroblast proliferation	biological process	IEA	7
GO:0070141	response to UV-A	biological process	IDA[18483258]	2
GO:0042327	positive regulation of phosphorylation	biological process	IDA[15082764]	3
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0035690	cellular response to drug	biological process	IEA	13
GO:0016324	apical plasma membrane	cellular component	IEA	24
GO:0035413	positive regulation of catenin import into nucleus	biological process	IMP[20302655]	2
GO:0001889	liver development	biological process	IEA	14
GO:0043066	negative regulation of apoptotic process	biological process	IMP[18070883]	46
GO:0001948	glycoprotein binding	molecular function	IEA	4
GO:0070435	Shc-EGFR complex	cellular component	ISS	1
GO:0071260	cellular response to mechanical stimulus	biological process	IEA	12
GO:0007166	cell surface receptor signaling pathway	biological process	IDA[7736574]	23
GO:0033594	response to hydroxyisoflavone	biological process	IEA	1
GO:0006950	response to stress	biological process	NAS[12828935]	5
GO:0005178	integrin binding	molecular function	IEA	8
GO:0030335	positive regulation of cell migration	biological process	IMP[12435727]	16
GO:0001503	ossification	biological process	NAS[12925580]	5
GO:0097489	multivesicular body, internal vesicle lumen	cellular component	IDA[17714434]	1
GO:0007611	learning or memory	biological process	ISS	13
GO:0019694	alkanesulfonate metabolic process	biological process	IEA	1
GO:0046982	protein heterodimerization activity	molecular function	IDA[10572067]	42
GO:0000186	activation of MAPKK activity	biological process	IEA	6
GO:0019899	enzyme binding	molecular function	IPI[12009895]	34
GO:0050679	positive regulation of epithelial cell proliferation	biological process	IDA[10572067]	9
GO:0008284	positive regulation of cell proliferation	biological process	IDA[7736574]	44
GO:0045739	positive regulation of DNA repair	biological process	IDA[17115032]	4
GO:0042698	ovulation cycle	biological process	IEA	2
GO:0007165	signal transduction	biological process	IDA[10572067]; TAS	136
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IDA[12828935]	13
GO:0004713	protein tyrosine kinase activity	molecular function	IDA[17115032]; IMP[14702346]; TAS[16076471]	9
GO:0071230	cellular response to amino acid stimulus	biological process	IEA	6
GO:0048143	astrocyte activation	biological process	IEA	2
GO:0030122	AP-2 adaptor complex	cellular component	TAS[14702346]	1
GO:0048015	phosphatidylinositol-mediated signaling	biological process	TAS	17
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0032930	positive regulation of superoxide anion generation	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[10026169]	563
GO:0001942	hair follicle development	biological process	IEA	4
GO:0042743	hydrogen peroxide metabolic process	biological process	IEA	1
GO:0031965	nuclear membrane	cellular component	IEA	15
GO:0003682	chromatin binding	molecular function	IDA[20551055]	23
GO:0060571	morphogenesis of an epithelial fold	biological process	IEA	1
GO:0001934	positive regulation of protein phosphorylation	biological process	IDA[20551055]	15
GO:0005768	endosome	cellular component	IDA[14702346]	27
GO:0016323	basolateral plasma membrane	cellular component	IDA[12646923]	21
GO:0000165	MAPK cascade	biological process	NAS[15542601]	10
GO:0010008	endosome membrane	cellular component	IDA[22719997]	17
GO:0006979	response to oxidative stress	biological process	IEA	11
GO:0050999	regulation of nitric-oxide synthase activity	biological process	IDA[12828935]	6
GO:0016337	single organismal cell-cell adhesion	biological process	IMP[12435727]	10
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[10572067]	6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[20551055]	91
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0001892	embryonic placenta development	biological process	IEA	1
GO:0045907	positive regulation of vasoconstriction	biological process	IEA	12
GO:0030324	lung development	biological process	IEA	9
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	8
GO:0051205	protein insertion into membrane	biological process	TAS[12435727]	1
GO:0008283	cell proliferation	biological process	IDA[17115032]	37
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	21
GO:0006970	response to osmotic stress	biological process	IEA	1
GO:0048546	digestive tract morphogenesis	biological process	IEA	2
GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle	biological process	IDA[18483258]	2
GO:0031901	early endosome membrane	cellular component	IDA[17714434]	8
GO:0051897	positive regulation of protein kinase B signaling	biological process	IMP[17655843]	11
GO:0048408	epidermal growth factor binding	molecular function	IEA	1
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0071392	cellular response to estradiol stimulus	biological process	IDA[20551055]	8
GO:0071364	cellular response to epidermal growth factor stimulus	biological process	ISS	3
GO:0019903	protein phosphatase binding	molecular function	IPI[15899872]	5
GO:0005524	ATP binding	molecular function	IEA	118
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	52
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	biological process	TAS	1
GO:0007202	activation of phospholipase C activity	biological process	TAS[12435727]	15
GO:0043586	tongue development	biological process	IEA	2
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50

Gene related KEGG pathways (count: 18)

KEGG pathways by PBA (count: 6)

ID	Name	No. of Genes in BDgene
hsa04540	Gap junction	15
hsa04510	Focal adhesion	22
hsa05214	Glioma	9
hsa04010	MAPK signaling pathway	39
hsa04020	Calcium signaling pathway	53
hsa05219	Bladder cancer	3

KEGG pathways by database search (count: 12)

ID	Name	No. of Genes in BDgene
hsa04520	Adherens junction	11
hsa05210	Colorectal cancer	14
hsa05213	Endometrial cancer	10
hsa05212	Pancreatic cancer	10
hsa05215	Prostate cancer	18
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11
hsa04012	ErbB signaling pathway	13
hsa04060	Cytokine-cytokine receptor interaction	17
hsa05218	Melanoma	7
hsa04912	GnRH signaling pathway	17
hsa05223	Non-small cell lung cancer	8
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 15)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 15)

ID	Name	No. of Genes in BDgene
tffPathway	Trefoil Factors Initiate Mucosal Healing	4
her2Pathway	Role of ERBB2 in Signal Transduction and Oncology	7
agrPathway	Agrin in Postsynaptic Differentiation	8
keratinocytePathway	Keratinocyte Differentiation	5
egfr_smrtePathway	Map Kinase Inactivation of SMRT Corepressor	3
mCalpainPathway	mCalpain and friends in Cell motility	3
At1rPathway	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	4
cardiacegfPathway	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	5
telPathway	Telomeres, Telomerase, Cellular Aging, and Immortality	4
eea1Pathway	The role of FYVE-finger proteins in vesicle transport	2
cblPathway	CBL mediated ligand-induced downregulation of EGF receptors	1
spryPathway	Sprouty regulation of tyrosine kinase signals	1
egfPathway	EGF Signaling Pathway	5
erkPathway	Erk1/Erk2 Mapk Signaling pathway	3
ErbB3Pathway	Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling	2

Gene related interactors from protein-protein interactions data in HPRD (count: 155)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
EGFR	CTNND1	NO	in vitro;in vivo	14996911
EGFR	ITGA5	NO	in vitro;in vivo	10888683
EGFR	SCAMP3	NO	in vitro;in vivo	9658162 , 15144186
EGFR	CLTCL1	NO	in vivo	16799092
EGFR	SEC13	NO	in vivo	16799092
EGFR	KRT18	NO	in vitro;in vivo	12577067
EGFR	SOS1	NO	in vivo	9447973
EGFR	GRB2	NO	in vitro;in vivo	1322798 , 7527043 , 8662998 , 12577067 , 14679214 , 8887653 , 11726515 , 8810325 , 7518560 , 16799092
EGFR	AGTR1	YES	in vitro	12522132
EGFR	AMH	NO	in vitro	8596488
EGFR	MAP2K1	NO	in vitro;in vivo	12556561
EGFR	KRT8	NO	in vitro;in vivo	12577067
EGFR	BTC	NO	in vivo	9528863
EGFR	CDH1	NO	in vivo	10969083
EGFR	PITPNA	NO	in vitro;in vivo	7761838
EGFR	CAV3	YES	in vitro;in vivo	9374534
EGFR	HIST3H3	NO	in vitro;in vivo	12577067
EGFR	SCAMP1	NO	in vivo	9658162
EGFR	GAB1	NO	in vitro;in vivo	11432805 , 10734310
EGFR	HTT	YES	in vivo	9079622
EGFR	TGFA	NO	in vitro	12297049
EGFR	PLSCR1	NO	in vitro;in vivo	12009895 , 12871937
EGFR	PIK3C2B	NO	in vitro;in vivo	11533253 , 10805725
EGFR	SHC1	NO	in vitro;in vivo	9544989 , 8887653 , 12577067 , 16729043 , 7518560
EGFR	CRK	NO	in vitro;in vivo	9642287 , 12198159 , 11956190 , 8875975 , 9480911
EGFR	AREG	NO	in vivo	10085134
EGFR	ALCAM	NO	in vivo	16799092
EGFR	SNX6	NO	in vitro;in vivo	11279102
EGFR	GAPDH	NO	in vivo	16799092
EGFR	STAT1	NO	in vitro;in vivo	12070153 , 7657660 , 11294897 , 10918587 , 15322115 , 7543024 , 11839738 , 12817007 , 7690989 , 12637327
EGFR	XRCC6	NO	in vivo	9430697
EGFR	SNX2	NO	in vitro;in vivo	9819414
EGFR	CALM3	NO	in vitro;in vivo	12153558
EGFR	PRKAR1A	YES	in vivo	9050991
EGFR	TJP1	NO	in vivo	12708492
EGFR	EZR	NO	in vitro;in vivo	1382070 , 12560083
EGFR	PLD2	NO	in vitro;in vivo	9837959
EGFR	PTPN1	NO	in vitro;in vivo	8621392 , 7540771 , 10889023 , 12573287 , 11506178 , 9355745
EGFR	EPS15	NO	in vitro;in vivo	9049247 , 10953014
EGFR	ERRFI1	NO	in vivo;yeast 2-hybrid	11843178
EGFR	FER	NO	in vivo	7623846
EGFR	AR	NO	in vitro;in vivo	12534934 , 15288768
EGFR	VAV2	NO	in vitro;in vivo	10618391 , 10938113 , 12454019 , 11516622
EGFR	STAT5A	NO	in vivo	10358079
EGFR	CAMLG	NO	in vivo	12919676
EGFR	PDGFRB	YES	in vivo	9506992
EGFR	CAMK2A	YES	in vitro	1309762 , 10347170
EGFR	PTPRJ	NO	in vivo	9115287
EGFR	PKIA	YES	in vitro	2434500
EGFR	SOS2	NO	in vivo	10675333
EGFR	CALM2	NO	in vitro;in vivo	12153558
EGFR	ERBB3	NO	in vivo	10527633
EGFR	SLC3A2	NO	in vivo	16799092
EGFR	SOCS7	NO	in vitro	9344857
EGFR	GRB7	NO	in vitro;in vivo	9710451
EGFR	ADRBK1	NO	in vivo	15620700
EGFR	SGSM2	NO	yeast 2-hybrid	16169070
EGFR	ANXA1	YES	in vivo	15581623
EGFR	RASA1	NO	in vitro;in vivo	1633149 , 1850098
EGFR	YWHAZ	NO	in vitro;in vivo	15389569 , 15225635
EGFR	NCK1	NO	in vitro	9362449
EGFR	MAPK1	NO	in vitro;in vivo	12556561
EGFR	DCN	NO	in vitro;in vivo;yeast 2-hybrid	12105206 , 9988678
EGFR	CTNNB1	NO	in vivo	9233779
EGFR	EREG	NO	in vivo	9419975
EGFR	PIK3C2A	YES	in vivo	10805725
EGFR	STAT3	NO	in vitro	12873986
EGFR	SNX4	YES	in vivo	9819414
EGFR	EGF	NO	in vitro;in vivo	12093292 , 12620237 , 10788520 , 16274239 , 15620700 , 12297050
EGFR	SH2D3A	NO	in vivo	10187783
EGFR	MUC1	NO	in vitro;in vivo	11483589 , 11278868
EGFR	CALM1	NO	in vitro;in vivo	12153558
EGFR	SNRPD2	NO	in vitro;in vivo	12577067
EGFR	SFN	NO	in vivo	16799092
EGFR	PIK3R1	YES	in vivo	8662998
EGFR	CLTA	NO	in vivo	16799092
EGFR	PTPN11	NO	in vitro;in vivo	7673163 , 11223155 , 14560030 , 16729043
EGFR	VAV1	NO	in vivo	10938113
EGFR	ATP5C1	NO	yeast 2-hybrid	16169070
EGFR	PIK3R2	NO	in vivo	11172806
EGFR	KRT7	NO	in vitro;in vivo	12577067
EGFR	PDCD6IP	NO	in vivo	15557335
EGFR	ELF3	NO	in vitro	1651322
EGFR	ERBB4	YES	in vitro	10572067
EGFR	RIPK1	NO	in vivo	11116146
EGFR	ATP1B1	YES	in vivo	16799092
EGFR	PTK2B	YES	in vivo	10777553
EGFR	EPHA2	NO	in vivo	15657067
EGFR	PLEC1	NO	in vitro;in vivo	12577067
EGFR	CBLB	NO	in vitro;in vivo	10086340
EGFR	CAV1	NO	in vitro;in vivo	9374534 , 16799092
EGFR	EPPK1	NO	in vitro;in vivo	12577067
EGFR	SOCS1	NO	in vivo	12070153
EGFR	STAM2	NO	in vitro;in vivo	11687594 , 10993906
EGFR	PAK1	NO	in vitro;in vivo	12522133
EGFR	FAS	NO	in vitro;in vivo	12586732
EGFR	SHC3	NO	in vivo	9507002
EGFR	DOK2	NO	in vitro	10508618
EGFR	TUBA1A	NO	in vivo	16799092
EGFR	STAT5B	NO	in vitro;in vivo	10558875 , 11751923
EGFR	PTK6	NO	in vivo	8940083
EGFR	HGS	NO	in vitro	12953068
EGFR	CEACAM1	NO	in vitro;in vivo	15467833
EGFR	CAV2	NO	in vivo	16799092
EGFR	PLCG1	YES	in vitro;in vivo	9207933 , 8885868 , 8657103 , 1689310 , 7682059 , 15144186 , 12601080
EGFR	CBLC	NO	in vitro;in vivo	10362357
EGFR	SOCS3	NO	in vitro;in vivo	12070153
EGFR	CDC25A	NO	in vitro;in vivo	11912208
EGFR	PRKACA	NO	in vivo	9050991
EGFR	HOXC10	NO	in vivo	16799092
EGFR	SH3BGRL3	NO	in vitro;in vivo	16729043
EGFR	PTPN2	NO	in vitro;in vivo	9488479 , 15588985
EGFR	ICAM1	NO	in vivo	16799092
EGFR	LYN	NO	in vivo	16799092
EGFR	GRB14	NO	in vitro;in vivo	8647858
EGFR	PRKCD	NO	in vivo	2987962 , 2984676
EGFR	ACTA1	NO	in vitro;in vivo	1808202 , 1383230
EGFR	GNAI2	YES	in vivo	11286993
EGFR	MT-CO2	NO	in vitro;in vivo	15282306
EGFR	PRKCA	NO	in vitro;in vivo	12878187
EGFR	MET	NO	in vitro;in vivo	10722725
EGFR	TNC	NO	in vitro;in vivo	11470832
EGFR	CEBPB	NO	in vitro;in vivo	12095417
EGFR	INPPL1	NO	in vitro;in vivo	11349134
EGFR	PTK2	NO	in vitro;in vivo	10806474
EGFR	SNX1	NO	in vivo;yeast 2-hybrid	9819414 , 8638121
EGFR	SLC9A3R1	NO	in vitro	16456542
EGFR	ERBB2	YES	in vitro;in vivo	11500850 , 12354693 , 1706616 , 11500516 , 16843263 , 17426253
EGFR	RGS16	NO	in vitro;in vivo	11602604 , 12588871
EGFR	EPB41	NO	in vitro;in vivo	1647028
EGFR	SOCS5	NO	in vivo	15695332
EGFR	MAP4K1	NO	in vivo	9346925
EGFR	SRC	NO	in vitro	11983694 , 8845374 , 10075741
EGFR	UBB	NO	in vivo	12218189
EGFR	HBEGF	YES	in vivo	12725245
EGFR	TNK2	YES	in vivo	8497321 , 8647288
EGFR	EPS8	NO	in vivo	7532293 , 12127568
EGFR	ZNF259	YES	in vivo	10938113 , 8650580
EGFR	MAP3K14	NO	in vivo	11116146
EGFR	PTPRS	NO	in vivo	10435588
EGFR	PTPN6	NO	in vitro;in vivo	9733788
EGFR	PRKD1	NO	in vivo	10523301 , 2984676 , 2987962
EGFR	CD44	NO	in vivo	12093135
EGFR	CAMK2G	NO	in vitro	1309762 , 10347170
EGFR	DEGS1	NO	in vitro;in vivo;yeast 2-hybrid	9188692
EGFR	CBL	NO	in vitro;in vivo	8662998 , 11994282 , 11239464 , 9890970 , 10092522 , 10799548 , 16729043 , 7657591 , 8798643 , 18273061
EGFR	CD82	NO	in vitro;in vivo	10985391
EGFR	S100A7	NO	in vivo	16799092
EGFR	KRT17	NO	in vitro;in vivo	12577067
EGFR	TUBA4A	NO	in vivo	16799092
EGFR	JAK2	NO	in vitro;in vivo	9363897 , 10635327
EGFR	VAV3	YES	in vivo	11094073
EGFR	GRB10	NO	in vitro;in vivo	9006901 , 9506989
EGFR	ARF4	NO	in vitro;in vivo;yeast 2-hybrid	12446727
EGFR	S100A9	NO	in vivo	16799092

Related other genetic factors

Gene related SNPs (count: 18)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs729969	chr7:55060514 - 55060514(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)
rs17172438	chr7:55083844 - 55083844(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

LD-proxies (count: 16)

rs_ID	Location	Functional Annotation
rs11979158	chr7:55091656 - 55091656(1)	intron_variant; non_coding_transcript_variant
rs11979406	chr7:55088754 - 55088754(1)	intron_variant; non_coding_transcript_variant
rs17172441	chr7:55089335 - 55089335(1)	intron_variant; non_coding_transcript_variant
rs759170	chr7:55087679 - 55087679(1)	intron_variant; non_coding_transcript_variant
rs17172440	chr7:55088317 - 55088317(1)	intron_variant; non_coding_transcript_variant
rs11974185	chr7:55086015 - 55086015(1)	intron_variant; non_coding_transcript_variant
rs11977299	chr7:55086082 - 55086082(1)	intron_variant; non_coding_transcript_variant
rs1015793	chr7:55046623 - 55046623(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7785013	chr7:55084974 - 55084974(1)	intron_variant; non_coding_transcript_variant
rs11984267	chr7:55086000 - 55086000(1)	intron_variant; non_coding_transcript_variant
rs10245472	chr7:55079785 - 55079785(1)	intron_variant; non_coding_transcript_variant
rs17172437	chr7:55082117 - 55082117(1)	intron_variant; non_coding_transcript_variant
rs17172433	chr7:55074742 - 55074742(1)	intron_variant; non_coding_transcript_variant
rs17172435	chr7:55078778 - 55078778(1)	intron_variant; non_coding_transcript_variant
rs17586365	chr7:55073093 - 55073093(1)	intron_variant; non_coding_transcript_variant
rs17172432	chr7:55073624 - 55073624(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p11-p13	chr7:43300000-59900000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
17893707	530	Negative
17598910	530	Positive

Gene relationship with MDD

View in gBrowse

Region: chr7:55019021..55211628 View in gBrowse