Gene Report

Basic Info
Approved Symbol ALDH2
Approved Name aldehyde dehydrogenase 2 family (mitochondrial)
Location 12q24.12
Position chr12:111766887-111817529, 1
External Links HGNC: 404
Entrez Gene: 217
Ensembl: ENSG00000111275
UCSC: uc001tst.3
No. of Studies 3 (Positive: 3; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Lee, S. Y., 2012 Other variant: ALDH2_*1*2 allele ALDH2*1*1: P-value = 0.002, OR(95% CI)=4.48(1.76-11.40) in BP-I, P-value = 0.425, OR(95% CI)=1.34(0.66-2.73) in BP-II. The regression showed a significant association of the ALDH2 with BP-I only. Positive Comment on Study
Lee, S. Y.,2010 Haplotype: ALDH2_*1/*2 - rs1800497((ALDH2_1*1*)-(DRD2 Taq-I A1/A2)), ALDH2_*1/*2 - rs1800497((ALDH2_1*1*)-(DRD2Taq-I A1/A1))
Other variant: ALDH2_*1/*2
Our findings may provide initial evidence that the ALDH2 and DRD2/ANKK1 genes interact in specific subtypes of bipolar disorders. Our findings also suggest a unique genetic distinction between bipolar I and bipolar II disorders. Positive Comment on Study
Wang, Y. S., 2013 a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 1)

GO terms by database search (count: 12)

Gene related KEGG pathways (count: 15)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:111766887..111817529 View in gBrowse
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