Gene Report

Basic Info
Approved Symbol NPAS2
Symbol Alias MOP4, PASD4, bHLHe9
Approved Name neuronal PAS domain protein 2
Location 2q11.2
Position chr2:100820152-100996829, 1
External Links HGNC: 7895
Entrez Gene: 4862
Ensembl: ENSG00000170485
UCSC: uc002tap.1
No. of Studies 5 (Positive: 3; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kripke, D. F.,2009 SNP: rs1562313 Significant association was observed in the BP group. Positive Comment on Study
Mansour, H. A.,2009 SNP: rs11123857, rs13025524, rs17025005, rs6543004 Gene-based tests:X<sup>2</sup>=6.629, P-value = 0.326 in additive model, X<sup>2</sup>=5.686, P-value = 0.553 in dominant model, X<sup>2</sup>=5.077, P-value = 0.701 in recessive model in BPI. Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. Positive Comment on Study
Soria, V.,2010 SNP: rs11123857, rs11541353, rs13025524, rs13394520, rs17025005, rs17662394, rs2117713, rs3754674, rs4851392, rs7581886 Significant associations of NPAS2 gene were found in BPD patients. Positive Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Byrne, E. M., 2014 P-value=0.47. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 27)

GO terms by PBA (count: 5)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 21)

Literature-origin SNPs (count: 12)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr2:100820152..100996829 View in gBrowse
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