Gene Report

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Basic Info

Approved Symbol	TRIB1
Symbol Alias	C8FW, GIG2, TRB1
Approved Name	tribbles pseudokinase 1
Previous Name	tribbles homolog 1 (Drosophila)
Location	8q24.13
Position	chr8:125430321-125438405, 1
External Links	HGNC: 16891 Entrez Gene: 10221 Ensembl: ENSG00000173334 UCSC: uc003yrx.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs10956248, rs921720, rs2124036, rs1488019 Other variant: TRIB1_Chr8:126514759	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004672	protein kinase activity	molecular function	TAS[20410507]	13
GO:0005634	nucleus	cellular component	IDA[17452330]	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	TAS[20410507]	118
GO:0043405	regulation of MAP kinase activity	biological process	IDA[15299019]	1
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IMP[15299019]; ISS[17724128]	6
GO:0004860	protein kinase inhibitor activity	molecular function	IMP[15299019]	2
GO:0005737	cytoplasm	cellular component	IDA[17452330]	322
GO:0007254	JNK cascade	biological process	IMP[17452330]	8
GO:0055106	ubiquitin-protein transferase regulator activity	molecular function	ISS[20410507]	1
GO:0032496	response to lipopolysaccharide	biological process	IMP[17452330]; ISS[17724128]	22
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	IBA; ISS[20410507]	7
GO:0006468	protein phosphorylation	biological process	TAS[20410507]	42
GO:0006469	negative regulation of protein kinase activity	biological process	IMP[15299019]	7
GO:0014912	negative regulation of smooth muscle cell migration	biological process	IMP[17452330]	2
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	biological process	IMP[17452330]	1
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IMP[17452330]	7
GO:0031625	ubiquitin protein ligase binding	molecular function	ISS[20410507]	25
GO:0008134	transcription factor binding	molecular function	IPI[17724128]	28
GO:0031434	mitogen-activated protein kinase kinase binding	molecular function	IDA[15299019]	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TRIB1	MAP2K1	NO	in vivo	15299019
TRIB1	MAP2K7	NO	in vivo	15299019
TRIB1	MAP2K4	NO	in vivo	15299019

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs921720	chr8:125522429 - 125522429(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1488019	chr8:126230474 - 126230474(1)		1(0/0/1)
rs2124036	chr8:125635890 - 125635890(1)		1(0/1/0)
rs10956248	chr8:125461199 - 125461199(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
TRIB1_Chr8:126514759		Exonic	1 (0/0/1)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.13	chr8:121500000-126300000	1 (0/0/1)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:125430321..125438405 View in gBrowse