Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ARHGAP15
Symbol Alias	BM046
Approved Name	Rho GTPase activating protein 15
Location	2q22.2-q22.3
Position	chr2:143091362-143768352, 1
External Links	HGNC: 21030 Entrez Gene: 55843 Ensembl: ENSG00000075884 UCSC: uc002tvm.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10048784, rs10803491, rs11680245, rs12615880, rs13004397, rs16822430, rs4430884	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IEA	137

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005096	GTPase activator activity	molecular function	IDA[12650940]	19
GO:0043547	positive regulation of GTPase activity	biological process	IDA[12650940]; IEA	30
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0008360	regulation of cell shape	biological process	IDA[12650940]	16
GO:0005829	cytosol	cellular component	TAS	223
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ARHGAP15	CD93	NO	yeast 2-hybrid	15459234
ARHGAP15	TGFBR1	NO	in vivo	15761153
ARHGAP15	SMURF1	NO	in vivo	15761153
ARHGAP15	RAC1	YES	in vitro	12650940

Related other genetic factors

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4430884	chr2:143468060 - 143468060(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs11680245	chr2:143360850 - 143360850(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10048784	chr2:143410468 - 143410468(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs12615880	chr2:143505975 - 143505975(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs16822430	chr2:143389906 - 143389906(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10803491	chr2:143338010 - 143338010(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs13004397	chr2:143471978 - 143471978(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 18)

rs_ID	Location	Functional Annotation
rs6731065	chr2:143501671 - 143501671(1)	intron_variant; non_coding_transcript_variant
rs13020925	chr2:143505847 - 143505847(1)	intron_variant; non_coding_transcript_variant
rs12464672	chr2:143496535 - 143496535(1)	intron_variant; non_coding_transcript_variant
rs12996951	chr2:143501082 - 143501082(1)	intron_variant; non_coding_transcript_variant
rs4560048	chr2:143493566 - 143493566(1)	intron_variant; non_coding_transcript_variant
rs13024145	chr2:143494220 - 143494220(1)	intron_variant; non_coding_transcript_variant
rs12478031	chr2:143485738 - 143485738(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3795872	chr2:143487718 - 143487718(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs11676696	chr2:143362184 - 143362184(1)	intron_variant; non_coding_transcript_variant
rs11897813	chr2:143410351 - 143410351(1)	intron_variant; non_coding_transcript_variant
rs11690735	chr2:143483425 - 143483425(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12617059	chr2:143480794 - 143480794(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12616939	chr2:143480541 - 143480541(1)	intron_variant; non_coding_transcript_variant
rs6736101	chr2:143457062 - 143457062(1)	intron_variant; non_coding_transcript_variant
rs5025201	chr2:143448507 - 143448507(1)	intron_variant; non_coding_transcript_variant
rs13011344	chr2:143428976 - 143428976(1)	intron_variant; non_coding_transcript_variant
rs16822524	chr2:143425710 - 143425710(1)	intron_variant; non_coding_transcript_variant
rs12998761	chr2:143400896 - 143400896(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q22.1-q23.3	chr2:136100000-154000000	1 (0/1/0)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr2:143091362..143768352 View in gBrowse