Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	ARHGAP15
Symbol Alias	BM046
Approved Name	Rho GTPase activating protein 15
Location	2q22.2-q22.3
Position	chr2:143091362-143768352, 1
External Links	HGNC: 21030 Entrez Gene: 55843 Ensembl: ENSG00000075884 UCSC: uc002tvm.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10048784, rs10803491, rs11680245, rs12615880, rs13004397, rs16822430, rs4430884	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IEA	137

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005096	GTPase activator activity	molecular function	IDA[12650940]	19
GO:0043547	positive regulation of GTPase activity	biological process	IDA[12650940]; IEA	30
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0008360	regulation of cell shape	biological process	IDA[12650940]	16
GO:0005829	cytosol	cellular component	TAS	223
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ARHGAP15	CD93	NO	yeast 2-hybrid	15459234
ARHGAP15	RAC1	YES	in vitro	12650940
ARHGAP15	TGFBR1	NO	in vivo	15761153
ARHGAP15	SMURF1	NO	in vivo	15761153

Related other genetic factors

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4430884	chr2:143468060 - 143468060(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs11680245	chr2:143360850 - 143360850(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10048784	chr2:143410468 - 143410468(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs12615880	chr2:143505975 - 143505975(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs16822430	chr2:143389906 - 143389906(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10803491	chr2:143338010 - 143338010(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs13004397	chr2:143471978 - 143471978(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 18)

rs_ID	Location	Functional Annotation
rs6731065	chr2:143501671 - 143501671(1)	intron_variant; non_coding_transcript_variant
rs13020925	chr2:143505847 - 143505847(1)	intron_variant; non_coding_transcript_variant
rs12464672	chr2:143496535 - 143496535(1)	intron_variant; non_coding_transcript_variant
rs12996951	chr2:143501082 - 143501082(1)	intron_variant; non_coding_transcript_variant
rs4560048	chr2:143493566 - 143493566(1)	intron_variant; non_coding_transcript_variant
rs13024145	chr2:143494220 - 143494220(1)	intron_variant; non_coding_transcript_variant
rs12478031	chr2:143485738 - 143485738(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3795872	chr2:143487718 - 143487718(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs11676696	chr2:143362184 - 143362184(1)	intron_variant; non_coding_transcript_variant
rs11897813	chr2:143410351 - 143410351(1)	intron_variant; non_coding_transcript_variant
rs11690735	chr2:143483425 - 143483425(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12617059	chr2:143480794 - 143480794(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs12616939	chr2:143480541 - 143480541(1)	intron_variant; non_coding_transcript_variant
rs6736101	chr2:143457062 - 143457062(1)	intron_variant; non_coding_transcript_variant
rs5025201	chr2:143448507 - 143448507(1)	intron_variant; non_coding_transcript_variant
rs13011344	chr2:143428976 - 143428976(1)	intron_variant; non_coding_transcript_variant
rs16822524	chr2:143425710 - 143425710(1)	intron_variant; non_coding_transcript_variant
rs12998761	chr2:143400896 - 143400896(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q22.1-q23.3	chr2:136100000-154000000	1 (0/1/0)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:143091362..143768352 View in gBrowse