Gene Report

Basic Info
Approved Symbol HTR3A
Previous Symbol HTR3
Symbol Alias 5-HT3R, 5-HT3A
Approved Name 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
Previous Name 5-hydroxytryptamine (serotonin) receptor 3A
Location 11q23.1-q23.2
Position chr11:113974881-113990313, 1
External Links HGNC: 5297
Entrez Gene: 3359
Ensembl: ENSG00000166736
UCSC: uc010rxa.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Niesler, B.,2001(a) Other variant: HTR3A_C195T, HTR3A_C178T These findings show that the C178T(Pro16Ser) variant in HTR3A may represent a functional variant and affect the susceptibility to bipolar disorder. Positive Comment on Study
Niesler, B.,2001(b) Other variant: HTR3A_exon1_Leu10Leu, HTR3A_exon3_A(+7 IVS3)C, HTR3A_exon6_Leu192Leu, HTR3A_exon7_Lys277Lys, HTR3A_exon8_Arg344His, HTR3A_exon9_Leu459Leu, HTR3A_exon9_Pro391Arg These results suggest that the observed mutations in HTR3A are rare and therefore do not play a major role in the aetiology of the disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 22)

GO terms by PBA (count: 7)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 9)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

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Region: chr11:113974881..113990313 View in gBrowse
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