Gene Report

Basic Info
Approved Symbol GABRA4
Approved Name gamma-aminobutyric acid (GABA) A receptor, alpha 4
Name Alias GABA(A) receptor, alpha 4
Location 4p12
Position chr4:46918900-46994407, -1
External Links HGNC: 4078
Entrez Gene: 2557
Ensembl: ENSG00000109158
UCSC: uc021xnz.1
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ament, S. A., 2015 P-value=0.0011, OR=14.9. No individual gene had a significant burden of segregating rare variants in BD pedigrees after correcting for multiple tests, although several genes had suggestive trends. Positive Comment on Study
Craddock, N., 2010 SNP: rs3934674 logistic regression for gene-wide P-value = 0.013. gene-wide levels of statistical significance in RDC SABP samples, but not other subsets of samples. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 17)

GO terms by PBA (count: 7)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 2)

BioCarta pathways by database search (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr4:46918900..46994407 View in gBrowse
View in gBrowse