Gene Report

Basic Info
Approved Symbol OTX2
Approved Name orthodenticle homeobox 2
Previous Name orthodenticle homolog 2 (Drosophila)
Location 14q22.3
Position chr14:56799905-56810479, -1
External Links HGNC: 8522
Entrez Gene: 5015
Ensembl: ENSG00000165588
UCSC: uc031qor.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sabunciyan, S., 2007 SNP: rs28757218 The variations in OTX2 might confer risk for the development of bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 29)

GO terms by PBA (count: 2)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr14:56799905..56810479 View in gBrowse
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