Gene Report

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Basic Info

Approved Symbol	GPR78
Approved Name	G protein-coupled receptor 78
Location	4p16.1
Position	chr4:8558725-8619761, 1
External Links	HGNC: 4528 Entrez Gene: 27201 Ensembl: ENSG00000155269 UCSC: uc003glk.4
No. of Studies	2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs11736084, rs1282, rs17844778, rs9685931, rs9799720	Significant association of SNP in this gene with BD in our population was observed.	Positive	Comment on Study
Underwood, S. L., 2006	SNP: rs11736084, rs1282, rs17844778, rs3756179, rs9685931, rs9799720 Haplotype: rs11736084 - rs1282 - rs17844778 - rs9685931(T-C-C-G), rs11736084 - rs1282 - rs17844778 - rs9685931 - rs9799720(T-C-C-G-C)	Our results provide preliminary evidence for the involvement of GPR78 in susceptibility to BPAD and SCZ in the Scottish population	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004930	G-protein coupled receptor activity	molecular function	IDA[17363172]	26
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IDA[17363172]	11

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11736084	chr4:8572220 - 8572220(1)	intron_variant; non_coding_transcript_variant	2(0/2/0)
rs9799720	chr4:8587621 - 8587621(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	2(1/1/0)
rs9685931	chr4:8587296 - 8587296(1)	intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	2(0/2/0)
rs3756179	chr4:8590980 - 8590980(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1282	chr4:8578031 - 8578031(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	2(1/1/0)
rs17844778	chr4:8581585 - 8581585(1)	downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs9799378	chr4:8587987 - 8587987(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs4391014	chr4:8586548 - 8586548(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4696852	chr4:8586491 - 8586491(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs9799717	chr4:8587536 - 8587536(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs9799809	chr4:8587689 - 8587689(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs9799721	chr4:8587709 - 8587709(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p16.1	chr4:6000000-11300000	2 (0/2/0)
4p16	chr4:0-11300000	2 (0/1/1)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16389273	Our results provide preliminary evidence for the involvement of GPR78 in susceptibility to BPAD and SCZ in the Scottish population	Positive

Reference	ID in SZGene	Result Category
16389273	55	Positive
19158809	55	Negative

Gene relationship with MDD

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Region: chr4:8558725..8619761 View in gBrowse