Gene Report

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Basic Info

Approved Symbol	TAAR8
Previous Symbol	GPR102, TRAR5
Symbol Alias	TA5, TAR5
Approved Name	trace amine associated receptor 8
Previous Name	trace amine receptor 5
Location	6q23.2
Position	chr6:132552693-132553721, 1
External Links	HGNC: 14964 Entrez Gene: 83551 Ensembl: ENSG00000146385 UCSC: uc011ecj.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R.,2005(b)	SNP: rs7772821, rs8192627	We observed no significant TDT results in TRAR5.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IC[15718104]	219
GO:0005887	integral component of plasma membrane	cellular component	IBA	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[15718104]	64
GO:0007606	sensory perception of chemical stimulus	biological process	IBA	14
GO:0001594	trace-amine receptor activity	molecular function	IBA	4
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IBA	16
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[15718104]	26

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7772821	chr6:132571367 - 132571367(1)	downstream_gene_variant	2(0/2/0)
rs8192627	chr6:132553675 - 132553675(1)	missense_variant	1(0/1/0)
rs1933988	chr6:132550514 - 132550514(1)	upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2255292		chr6:132558161 - 132558161(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q23	chr6:130000000-138300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:132552693..132553721 View in gBrowse