GO Report

Basic Info

ID	GO:0003700
Name	sequence-specific DNA binding transcription factor activity
Type	molecular function
No. of Genes in BDgene	66
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
GO:03700: transcription factor activity	PBA paper	Holmans, P., 2009	WTCCC+STEP-UCL+ED-DUB-STEP2	ALIGATOR (Association LIst Go AnnoTatOR)	FUNCTION, cutoff for significant SNPs: p < 0.01
GO: 0003700: transcription factor act.	PBA paper	Askland, K.,2009	WTCCC Bayesian genotypic	Fisher's exact test	P < 0.05 from the WTCCC PBAs

GO related genes in BDgene (count: 66)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
EGR2	early growth response 2	10q21.1	3(1/2/0)	IDA[14532282]
EGR1	early growth response 1	5q23-q31	1(0/1/0)	IDA[12560508]
HES1	hes family bHLH transcription factor 1	3q28-q29	1(0/1/0)	IDA[17681138]
CSRNP2	cysteine-serine-rich nuclear protein 2	12q13.11-q13.12	1(0/1/0)	ISS[17726538]
ZNF74	zinc finger protein 74	22q11.2	1(0/1/0)	IBA
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	19p13.3	4(0/3/1)	TAS[7590749]
CREB1	cAMP responsive element binding protein 1	2q34	2(1/1/0)	IDA[8798441]
CREBBP	CREB binding protein	16p13.3	1(0/1/0)	TAS[7913207]
TFAM	transcription factor A, mitochondrial	10q21	1(1/0/0)	IMP[22037171]
RNF4	ring finger protein 4	4p16.3	1(0/0/1)	TAS[9710597]
ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	12p12.2-p11.2	3(1/2/0)	IDA[12055078]; NAS[11018023]
ZKSCAN4	zinc finger with KRAB and SCAN domains 4	6p21	1(1/0/0)	IEA
YY1	YY1 transcription factor	14q	1(0/1/0)	TAS[1946405]
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	11p15.4	1(0/1/0)	IDA[18579750]
RORA	RAR-related orphan receptor A	15q21-q22	3(2/1/0)	IDA[11053433]
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5q31-q32	5(2/3/0)	IDA[15769988]
RFX4	regulatory factor X, 4 (influences HLA class II expression)	12q24	2(1/1/0)	IBA
HSF2	heat shock transcription factor 2	6q22	1(1/0/0)	TAS[1871106]
FOXO3	forkhead box O3	6q21	1(1/0/0)	IDA[14734530]
RORB	RAR-related orphan receptor B	9q22	4(3/1/0)	ISS
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	12q23	1(0/1/0)	NAS[7851904]
PPARD	peroxisome proliferator-activated receptor delta	6p21.2	1(1/0/0)	IDA[12955147]; NAS[11551955]
PAX8	paired box 8	2q13	1(0/0/1)	IDA[9388203]
GSC2	goosecoid homeobox 2	22q11.21	1(0/1/0)	IDA[9700206]
ZIC2	Zic family member 2	13q32	1(0/1/0)	ISS
NFIA	nuclear factor I/A	1p31.3-p31.2	1(0/1/0)	NAS[7590749]
ZHX2	zinc fingers and homeoboxes 2	8q24.13	1(0/0/1)	IDA[12741956]
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	20q11	1(0/0/1)	IEA
THRA	thyroid hormone receptor, alpha	17q21.1	1(1/0/0)	IDA[18052923]
GLI2	GLI family zinc finger 2	2q14	1(0/1/0)	IDA[15994174]
EGR4	early growth response 4	2p13	1(0/1/0)	NAS[1584812]
ZNF490	zinc finger protein 490	19p13.2	1(1/0/0)	IBA
ESR1	estrogen receptor 1	6q24-q27	1(0/1/0)	NAS[12552091]
ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	15q25.1	1(0/1/0)	ISS
ZNF274	zinc finger protein 274	19q13.43	2(1/1/0)	IEA
CREM	cAMP responsive element modulator	10p12.1-p11.1	1(0/1/0)	IEA
FOXN3	forkhead box N3	14q32.11	1(1/0/0)	IEA
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	2p11.2	1(0/1/0)	NAS[11085512]
TCF4	transcription factor 4	18q21.1	6(1/5/0)	IDA[11802795]
ZXDC	ZXD family zinc finger C	3q21.3	1(0/1/0)	IMP[17493635]
TULP4	tubby like protein 4	6q25-q26	1(1/0/0)	NAS[11595174]
EGR3	early growth response 3	8p23-p21	3(2/1/0)	TAS[1906159]
POU3F2	POU class 3 homeobox 2	6q16.2	1(1/0/0)	IEA
EBF1	early B-cell factor 1	5q34	1(1/0/0)	IEA
HOXA3	homeobox A3	7p15.2	1(1/0/0)	IEA
XBP1	X-box binding protein 1	22q12.1	3(2/1/0)	IDA[1903538]
POU6F2	POU class 6 homeobox 2	7p14.1	1(1/0/0)	TAS[8601806]
TBP	TATA box binding protein	6q27	1(0/1/0)	IEA
HNF4A	hepatocyte nuclear factor 4, alpha	20q13.12	1(1/0/0)	IDA[10330009]
AFF1	AF4/FMR2 family, member 1	4q21.3	1(0/1/0)	TAS[7689231]
CLOCK	clock circadian regulator	4q12	12(5/7/0)	ISS
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	10q25.3	1(1/0/0)	IDA[9727977]
ZSCAN31	zinc finger and SCAN domain containing 31	6p	1(1/0/0)	IEA
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	6p12	1(0/1/0)	IDA[11505339]
MEOX2	mesenchyme homeobox 2	7p22.1-p21.3	1(1/0/0)	IDA[22206000]
GLI3	GLI family zinc finger 3	7p13	1(1/0/0)	IDA[10077605]
NFIL3	nuclear factor, interleukin 3 regulated	9q22	2(0/2/0)	TAS[7565758]
HMG20A	high mobility group 20A	15q24	1(1/0/0)	NAS[10773667]
FOXP2	forkhead box P2	7q31	2(0/2/0)	IDA[18987363]
AHR	aryl hydrocarbon receptor	7p15	1(1/0/0)	IDA[11782478]
IRF2	interferon regulatory factor 2	4q34.1-q35.1	1(1/0/0)	IMP[9540062]
NR3C2	nuclear receptor subfamily 3, group C, member 2	4q31	1(1/0/0)	IEA
NPAS2	neuronal PAS domain protein 2	2q11.2	5(3/2/0)	IEA
ATF4	activating transcription factor 4	22q13.1	1(1/0/0)	ISS; TAS[12689582]
MYT1L	myelin transcription factor 1-like	2p25.3	1(1/0/0)	IEA
MKL2	MKL/myocardin-like 2	16p13.12	1(0/0/1)	IEA