GO Report

Basic Info
ID GO:0003700
Name sequence-specific DNA binding transcription factor activity
Type molecular function
No. of Genes in BDgene  66
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
GO: 0003700: transcription factor act. PBA paper Askland, K.,2009 WTCCC Bayesian genotypic Fisher's exact test P < 0.05 from the WTCCC PBAs
GO:03700: transcription factor activity PBA paper Holmans, P., 2009 WTCCC+STEP-UCL+ED-DUB-STEP2 ALIGATOR (Association LIst Go AnnoTatOR) FUNCTION, cutoff for significant SNPs: p < 0.01

GO related genes in BDgene (count: 66)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) Evidence[PMID]
EGR2 early growth response 2 10q21.1 3(1/2/0) IDA[14532282]
EGR1 early growth response 1 5q23-q31 1(0/1/0) IDA[12560508]
HES1 hes family bHLH transcription factor 1 3q28-q29 1(0/1/0) IDA[17681138]
CSRNP2 cysteine-serine-rich nuclear protein 2 12q13.11-q13.12 1(0/1/0) ISS[17726538]
ZNF74 zinc finger protein 74 22q11.2 1(0/1/0) IBA
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 19p13.3 4(0/3/1) TAS[7590749]
CREB1 cAMP responsive element binding protein 1 2q34 2(1/1/0) IDA[8798441]
CREBBP CREB binding protein 16p13.3 1(0/1/0) TAS[7913207]
TFAM transcription factor A, mitochondrial 10q21 1(1/0/0) IMP[22037171]
RNF4 ring finger protein 4 4p16.3 1(0/0/1) TAS[9710597]
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 12p12.2-p11.2 3(1/2/0) IDA[12055078]; NAS[11018023]
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 6p21 1(1/0/0) IEA
YY1 YY1 transcription factor 14q 1(0/1/0) TAS[1946405]
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 11p15.4 1(0/1/0) IDA[18579750]
RORA RAR-related orphan receptor A 15q21-q22 3(2/1/0) IDA[11053433]
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0) IDA[15769988]
RFX4 regulatory factor X, 4 (influences HLA class II expression) 12q24 2(1/1/0) IBA
HSF2 heat shock transcription factor 2 6q22 1(1/0/0) TAS[1871106]
FOXO3 forkhead box O3 6q21 1(1/0/0) IDA[14734530]
RORB RAR-related orphan receptor B 9q22 4(3/1/0) ISS
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 1(0/1/0) NAS[7851904]
PPARD peroxisome proliferator-activated receptor delta 6p21.2 1(1/0/0) IDA[12955147]; NAS[11551955]
PAX8 paired box 8 2q13 1(0/0/1) IDA[9388203]
GSC2 goosecoid homeobox 2 22q11.21 1(0/1/0) IDA[9700206]
ZIC2 Zic family member 2 13q32 1(0/1/0) ISS
NFIA nuclear factor I/A 1p31.3-p31.2 1(0/1/0) NAS[7590749]
ZHX2 zinc fingers and homeoboxes 2 8q24.13 1(0/0/1) IDA[12741956]
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 20q11 1(0/0/1) IEA
THRA thyroid hormone receptor, alpha 17q21.1 1(1/0/0) IDA[18052923]
GLI2 GLI family zinc finger 2 2q14 1(0/1/0) IDA[15994174]
EGR4 early growth response 4 2p13 1(0/1/0) NAS[1584812]
ZNF490 zinc finger protein 490 19p13.2 1(1/0/0) IBA
ESR1 estrogen receptor 1 6q24-q27 1(0/1/0) NAS[12552091]
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 15q25.1 1(0/1/0) ISS
ZNF274 zinc finger protein 274 19q13.43 2(1/1/0) IEA
CREM cAMP responsive element modulator 10p12.1-p11.1 1(0/1/0) IEA
FOXN3 forkhead box N3 14q32.11 1(1/0/0) IEA
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2p11.2 1(0/1/0) NAS[11085512]
TCF4 transcription factor 4 18q21.1 6(1/5/0) IDA[11802795]
ZXDC ZXD family zinc finger C 3q21.3 1(0/1/0) IMP[17493635]
TULP4 tubby like protein 4 6q25-q26 1(1/0/0) NAS[11595174]
EGR3 early growth response 3 8p23-p21 3(2/1/0) TAS[1906159]
POU3F2 POU class 3 homeobox 2 6q16.2 1(1/0/0) IEA
EBF1 early B-cell factor 1 5q34 1(1/0/0) IEA
HOXA3 homeobox A3 7p15.2 1(1/0/0) IEA
XBP1 X-box binding protein 1 22q12.1 3(2/1/0) IDA[1903538]
POU6F2 POU class 6 homeobox 2 7p14.1 1(1/0/0) TAS[8601806]
TBP TATA box binding protein 6q27 1(0/1/0) IEA
HNF4A hepatocyte nuclear factor 4, alpha 20q13.12 1(1/0/0) IDA[10330009]
AFF1 AF4/FMR2 family, member 1 4q21.3 1(0/1/0) TAS[7689231]
CLOCK clock circadian regulator 4q12 12(5/7/0) ISS
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 10q25.3 1(1/0/0) IDA[9727977]
ZSCAN31 zinc finger and SCAN domain containing 31 6p 1(1/0/0) IEA
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(0/1/0) IDA[11505339]
MEOX2 mesenchyme homeobox 2 7p22.1-p21.3 1(1/0/0) IDA[22206000]
GLI3 GLI family zinc finger 3 7p13 1(1/0/0) IDA[10077605]
NFIL3 nuclear factor, interleukin 3 regulated 9q22 2(0/2/0) TAS[7565758]
HMG20A high mobility group 20A 15q24 1(1/0/0) NAS[10773667]
FOXP2 forkhead box P2 7q31 2(0/2/0) IDA[18987363]
AHR aryl hydrocarbon receptor 7p15 1(1/0/0) IDA[11782478]
IRF2 interferon regulatory factor 2 4q34.1-q35.1 1(1/0/0) IMP[9540062]
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(1/0/0) IEA
NPAS2 neuronal PAS domain protein 2 2q11.2 5(3/2/0) IEA
ATF4 activating transcription factor 4 22q13.1 1(1/0/0) ISS; TAS[12689582]
MYT1L myelin transcription factor 1-like 2p25.3 1(1/0/0) IEA
MKL2 MKL/myocardin-like 2 16p13.12 1(0/0/1) IEA