Gene Report

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Basic Info

Approved Symbol	IRF2
Approved Name	interferon regulatory factor 2
Location	4q34.1-q35.1
Position	chr4:184387713-184474580, -1
External Links	HGNC: 6117 Entrez Gene: 3660 Ensembl: ENSG00000168310 UCSC: uc003iwf.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs3775552	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IMP[9540062]	66
GO:0003677	DNA binding	molecular function	IDA[9540062]	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	10
GO:0008283	cell proliferation	biological process	TAS[8438157]	37
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IMP[9540062]	5
GO:0006355	regulation of transcription, DNA-templated	biological process	IMP[9540062]	62
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IMP[9540062]	10
GO:0005925	focal adhesion	cellular component	IDA	32
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IMP[9540062]	91
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	TAS[7507207]	62
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005829	cytosol	cellular component	TAS	223
GO:0060337	type I interferon signaling pathway	biological process	TAS	7
GO:0007596	blood coagulation	biological process	TAS	44
GO:0005515	protein binding	molecular function	IPI[21903422]	563
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	23
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IRF2	IRF2BP2	YES	in vivo;yeast 2-hybrid	12799427
IRF2	HMGN1	NO	in vitro;in vivo;yeast 2-hybrid	11025449
IRF2	STAT1	NO	in vitro	15778351
IRF2	KAT2B	NO	in vivo	11304541 , 10022868
IRF2	IRF8	YES	in vitro;in vivo	7768900
IRF2	EP300	NO	in vitro;in vivo	11304541
IRF2	NFKB1	NO	in vitro	8550813
IRF2	RELA	NO	in vitro	8550813
IRF2	IRF2BP1	NO	in vitro;in vivo;yeast 2-hybrid	12799427
IRF2	HMGB1	NO	in vitro	11748221
IRF2	CSNK2A1	YES	in vitro;in vivo	9213219

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3775552	chr4:184403033 - 184403033(1)	intron_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs724528		chr4:184402572 - 184402572(1)	intron_variant
rs809909		chr4:184403456 - 184403456(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q35	chr4:182300000-190214555	4 (0/1/3)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
19668376	Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).	Pos	IRF2

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Region: chr4:184387713..184474580 View in gBrowse