Gene Report

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Basic Info

Approved Symbol	KCNK10
Symbol Alias	K2p10.1, TREK-2, TREK2, PPP1R97
Approved Name	potassium channel, two pore domain subfamily K, member 10
Previous Name	potassium channel, subfamily K, member 10
Name Alias	protein phosphatase 1, regulatory subunit 97
Location	14q31
Position	chr14:88180103-88326907, -1
External Links	HGNC: 6273 Entrez Gene: 54207 Ensembl: ENSG00000100433 UCSC: uc001xwn.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0018. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005267	potassium channel activity	molecular function	TAS[10880510]	4
GO:0005887	integral component of plasma membrane	cellular component	IBA	158
GO:0005244	voltage-gated ion channel activity	molecular function	IEA	2

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	NAS[10880510]	136
GO:0071805	potassium ion transmembrane transport	biological process	IBA	9
GO:0022841	potassium ion leak channel activity	molecular function	IBA	1
GO:0030322	stabilization of membrane potential	biological process	IBA	1
GO:0034765	regulation of ion transmembrane transport	biological process	IEA	16
GO:0006810	transport	biological process	TAS[10880510]	47

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:88180103..88326907 View in gBrowse