Gene Report

Basic Info
Approved Symbol RORA
Symbol Alias RZRA, ROR1, ROR2, ROR3, NR1F1
Approved Name RAR-related orphan receptor A
Location 15q21-q22
Position chr15:60488284-61229319, -1
External Links HGNC: 10258
Entrez Gene: 6095
Ensembl: ENSG00000069667
UCSC: uc002agv.3
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Lai, Y. C., 2015 SNP: rs8041381, rs11632600, rs75981965, rs339998, rs2553236, rs13329238, rs17237353, rs1020729, rs1020730, rs12900122, rs8025689, rs9302215, rs1482057, rs11639084, rs12594188, rs10519067, rs11071557, rs11071558, rs922781, rs1963497, rs17270446, rs877228, rs16943117, rs12915776, rs6494227, rs79610262, rs35752305, rs16943172, rs75084363, rs8041466, rs11631432, rs2414686, rs12910281, rs2899664, rs11855147, rs79995443, rs72752802, rs74687025, rs4775350, rs782908, rs76824799, rs4774388, rs34720147, rs11631786 Gene-based association was significant for RORA gene (P = 0.0007).. Our results support for the involvement of RORs genes in the risk of developing BD. Positive Comment on Study
Soria, V.,2010 SNP: rs4774370 Significant associations of RORA gene were found in BPD patients. Positive Comment on Study
McGrath, C. L.,2009 There was no evidence for association between pediatric bipolar disorder and any RORA SNPs or haplotype blocks after multiple-test correction. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 48)

GO terms by PBA (count: 7)

GO terms by database search (count: 41)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Related other genetic factors
Gene related SNPs (count: 114)

Literature-origin SNPs (count: 47)

LD-proxies (count: 67)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr15:60488284..61229319 View in gBrowse
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