Gene Report

Basic Info
Approved Symbol DDC
Symbol Alias AADC
Approved Name dopa decarboxylase (aromatic L-amino acid decarboxylase)
Location 7p12.1
Position chr7:50458436-50565457, -1
External Links HGNC: 2719
Entrez Gene: 1644
Ensembl: ENSG00000132437
UCSC: uc003tpf.4
No. of Studies 5 (Positive: 2; Negative: 3; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ewald, H.,1995 Other variant: DDC_microsatellite polymorphisms For dominant models 2 and 3 the lod scores were below -2 at zero recombination fraction. No evidence of linkage to DDC was found Negative Comment on Study
Speight, G.,2000 Other variant: AADC_exon 1_T>A Case-control analysis did not suggest that genetic polymorphism in the AADC gene is associated with liability for developing schizophrenia or bipolar disorder. Negative Comment on Study
Borglum, A. D.,1999 Other variant: DDC_1bp_del, DDC_4bp_del Analyzing the combined material, a significant association was found between the 1-bp deletion and BPAD with P-values of 0.037 (allelic) and 0.021 (genotypic). The frequency of the 1-bp deletion was 13.3% in patients and 9.4% in controls with a corresponding odds ratio of 1. 48 (95% CI: 1.02-2.15). The results presented suggest that DDC may act as a minor susceptibility gene for bipolar affective disorder. Positive Comment on Study
Borglum, A. D.,2003 Other variant: DDC_4bp_del, DDC_1bp_del We suggest that DDC might confer susceptibility to BPAD predominantly when paternally transmitted. Positive Comment on Study
Jahnes, E.,2002 Other variant: DDC_1bp_del, DDC_4bp_del Thus, our results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 28)

GO terms by PBA (count: 1)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 5)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 5)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 8)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr7:50458436..50565457 View in gBrowse
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