Gene Report

Basic Info
Approved Symbol DRD5
Previous Symbol DRD1L2
Symbol Alias DRD1B
Approved Name dopamine receptor D5
Location 4p16.1
Position chr4:9781680-9784009, 1
External Links HGNC: 3026
Entrez Gene: 1816
Ensembl: ENSG00000169676
UCSC: uc003gmb.4
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kirov, G.,1999(a) Other variant: DRD5_(CT/GT/GA)n No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. Negative Comment on Study
Muir, W. J.,2001 Other variant: DRD5_D4S615 The data are consistent with an association between markers close to the D5 dopamine receptor and schizophrenia, but not bipolar disorder or unipolar major depression. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 32)

GO terms by PBA (count: 4)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 8)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr4:9781680..9784009 View in gBrowse
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