Gene Report

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Basic Info

Approved Symbol	BASP1
Symbol Alias	NAP-22, NAP22, CAP23, CAP-23
Approved Name	brain abundant, membrane attached signal protein 1
Location	5p15.1
Position	chr5:17065598-17276843, 1
External Links	HGNC: 957 Entrez Gene: 10409 Ensembl: ENSG00000176788 UCSC: uc031siz.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Goes, F. S.,2012	SNP: rs2962370	OR = 1.19,P-value(Meta) = 0.00000514 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003714	transcription corepressor activity	molecular function	IMP[14701728]	21
GO:0019904	protein domain specific binding	molecular function	IPI[14701728]	24
GO:0005634	nucleus	cellular component	IDA[14701728]	283
GO:0005886	plasma membrane	cellular component	IDA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0072075	metanephric mesenchyme development	biological process	ISS	1
GO:0060231	mesenchymal to epithelial transition	biological process	ISS	1
GO:2001076	positive regulation of metanephric ureteric bud development	biological process	ISS	1
GO:0060539	diaphragm development	biological process	ISS	2
GO:0008180	COP9 signalosome	cellular component	IDA[18850735]	4
GO:0016607	nuclear speck	cellular component	ISS	16
GO:0005515	protein binding	molecular function	IPI[19050011]	563
GO:0021762	substantia nigra development	biological process	IEP[22926577]	7
GO:0072112	glomerular visceral epithelial cell differentiation	biological process	ISS	2
GO:0005737	cytoplasm	cellular component	IDA[14701728]	322
GO:0060421	positive regulation of heart growth	biological process	ISS	1
GO:0005856	cytoskeleton	cellular component	TAS[9749536]	30
GO:0031982	vesicle	cellular component	IDA[19190083]	20
GO:0030426	growth cone	cellular component	IEA	22
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[19050011]; IMP[14701728]	43
GO:0030054	cell junction	cellular component	IDA	88
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0007356	thorax and anterior abdomen determination	biological process	ISS	1
GO:0008406	gonad development	biological process	ISS	1
GO:0044212	transcription regulatory region DNA binding	molecular function	ISS	17

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2962370	chr5:17215335 - 17215335(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5pter-p15.1	chr5:0-18400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17893707	588	Negative

Gene relationship with MDD

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Region: chr5:17065598..17276843 View in gBrowse