Gene Report

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Basic Info

Approved Symbol	CHRFAM7A
Symbol Alias	D-10, CHRNA7-DR1
Approved Name	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Location	15q13.2
Position	chr15:30357766-30393849, -1
External Links	HGNC: 15781 Entrez Gene: 89832 Ensembl: ENSG00000166664 UCSC: uc001zdt.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Flomen, R. H., 2006	Other variant: CHRFAM7A_2bp deletion	Overall genotype comparisons: bipolar versus controls: X<sup>2</sup>=6.96, 5 df, P-value = 0.2, psychosis versus controls: X<sup>2</sup>=7.26, 5 df, P-value = 0.2; CHRFAM7A wt comparisons (22 vs. 12/23 vs. 11/13/33): bipolar versus controls: X<sup>2</sup>=0.34, 2 df, P-value = 0.8, psychosis versus controls: X<sup>2</sup>=1.84, 2 df, P-value = 0.4. Comparison of genotype frequencies between schizophrenia or bipolar samples and controls show no significant difference, either analyzed separately or in the combined psychosis phenotype; no evidence for association of wild-type CHRFAM7A with schizophrenia, bipolar disorder or combined psychosis.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005230	extracellular ligand-gated ion channel activity	molecular function	IEA	11
GO:0034220	ion transmembrane transport	biological process	IEA	50

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
CHRFAM7A_2bp deletion	insertion/deletion		1 (0/1/0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16823804	Overall genotype comparisons: schizophrenia versus control: X<sup>2</sup>=8.00, 5 df, P-value = 0.2; CHRFAM7A wt comparisons (22 vs.12/23 vs.11/13/33): schizophrenia versus controls: X<sup>2</sup>=4.40, 2 df, P-value = 0.1. Comparison of genotype frequencies between schizophrenia or bipolar samples and controls show no significant difference, either analyzed separately or in the combined psychosis phenotype; no evidence for association of wild-type CHRFAM7A with schizophrenia, bipolar disorder or combined psychosis.	Negative

Gene relationship with MDD

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Region: chr15:30357766..30393849 View in gBrowse