Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	SEMA5A
Previous Symbol	SEMAF
Symbol Alias	semF
Approved Name	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Location	5p15.2
Position	chr5:9035026-9546075, -1
External Links	HGNC: 10736 Entrez Gene: 9037 Ensembl: ENSG00000112902 UCSC: uc003jek.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value < 0.0001. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 30)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0007399	nervous system development	biological process	TAS[9464278]	40
GO:0007155	cell adhesion	biological process	TAS[9049630]	42
GO:0007411	axon guidance	biological process	TAS	60
GO:0016020	membrane	cellular component	ISS	137

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008046	axon guidance receptor activity	molecular function	IEA	2
GO:0043395	heparan sulfate proteoglycan binding	molecular function	ISS	3
GO:0007413	axonal fasciculation	biological process	ISS	4
GO:0001938	positive regulation of endothelial cell proliferation	biological process	ISS	11
GO:2000352	negative regulation of endothelial cell apoptotic process	biological process	ISS	2
GO:0045766	positive regulation of angiogenesis	biological process	ISS	11
GO:0060326	cell chemotaxis	biological process	ISS	4
GO:0050918	positive chemotaxis	biological process	ISS	1
GO:0035413	positive regulation of catenin import into nucleus	biological process	ISS	2
GO:0001569	patterning of blood vessels	biological process	IEA	3
GO:0048843	negative regulation of axon extension involved in axon guidance	biological process	ISS	1
GO:0021536	diencephalon development	biological process	ISS	1
GO:0048842	positive regulation of axon extension involved in axon guidance	biological process	ISS	3
GO:0030836	positive regulation of actin filament depolymerization	biological process	ISS	1
GO:0007162	negative regulation of cell adhesion	biological process	ISS	5
GO:0051897	positive regulation of protein kinase B signaling	biological process	ISS	11
GO:0030215	semaphorin receptor binding	molecular function	ISS	1
GO:0045545	syndecan binding	molecular function	ISS	1
GO:0007267	cell-cell signaling	biological process	TAS[9464278]	29
GO:1990256	signal clustering	biological process	ISS	1
GO:2001028	positive regulation of endothelial cell chemotaxis	biological process	ISS	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0035373	chondroitin sulfate proteoglycan binding	molecular function	ISS	1
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	biological process	ISS	1