Gene Report

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Basic Info

Approved Symbol	JAZF1
Symbol Alias	TIP27, DKFZp761K2222, ZNF802
Approved Name	JAZF zinc finger 1
Location	7p15.2-p15.1
Position	chr7:27830573-28180743, -1
External Links	HGNC: 28917 Entrez Gene: 221895 Ensembl: ENSG00000153814 UCSC: uc003szn.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Lee, H. J., 2013	SNP: rs6971086, rs10274928, rs849139, rs864745, rs849141, rs1635853, rs530649, rs537124, rs552707, rs849320, rs550448	No significant association was found.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003714	transcription corepressor activity	molecular function	IDA[15302918]	21
GO:0005634	nucleus	cellular component	IEA	283
GO:0003676	nucleic acid binding	molecular function	IEA	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0017053	transcriptional repressor complex	cellular component	IDA[15302918]	5
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[15302918]	62
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
JAZF1	NR2C2	NO	in vitro;in vivo;yeast 2-hybrid	15302918

Related other genetic factors

Gene related SNPs (count: 19)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs849141	chr7:28145472 - 28145472(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs537124	chr7:28163523 - 28163523(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs864745	chr7:28140937 - 28140937(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs849139	chr7:28139777 - 28139777(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1635853	chr7:28149930 - 28149930(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs6971086	chr7:28098574 - 28098574(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs550448	chr7:28189423 - 28189423(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs10274928	chr7:28102469 - 28102469(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs530649	chr7:28162811 - 28162811(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs552707	chr7:28165684 - 28165684(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs849320	chr7:28169217 - 28169217(1)	intron_variant; NMD_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs3735568	chr7:28176035 - 28176035(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs17156432	chr7:28122786 - 28122786(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs4719925	chr7:28149376 - 28149376(1)	intron_variant; NMD_transcript_variant
rs4722755	chr7:28113217 - 28113217(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs12154248	chr7:28152756 - 28152756(1)	intron_variant; NMD_transcript_variant
rs12055996	chr7:28152174 - 28152174(1)	intron_variant; NMD_transcript_variant
rs3735569	chr7:28175742 - 28175742(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs964653	chr7:28154642 - 28154642(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr7:27830573..28180743 View in gBrowse