Gene Report

Basic Info
Approved Symbol GABRB3
Approved Name gamma-aminobutyric acid (GABA) A receptor, beta 3
Name Alias GABA(A) receptor, beta 3
Location 15q12
Position chr15:26543546-26939539, -1
External Links HGNC: 4083
Entrez Gene: 2562
Ensembl: ENSG00000166206
UCSC: uc001zba.4
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Papadimitriou, G. N.,2001 Other variant: GABRB3_(CA) repeat In conclusion, the GABRB3 CA-repeat polymorphism we investigated does not present the observed association between bipolar affective illness and GABRA5. Negative Comment on Study
Craddock, N., 2010 SNP: rs890319 set-based analysis for gene-wide P-value = 0.0107. gene-wide levels of statistical significance in RDC SABP samples, but not other subsets of samples. Positive Comment on Study
Duffy, A.,2000 Other variant: GABRB3_GDB160763 In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 6)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 7)

Literature-origin SNPs (count: 5)

LD-proxies (count: 2)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:26543546..26939539 View in gBrowse
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