Gene Report

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Basic Info

Approved Symbol	ZKSCAN4
Previous Symbol	ZNF307, ZNF427
Symbol Alias	p373c6.1, P1P373C6, FLJ32136, ZSCAN36
Approved Name	zinc finger with KRAB and SCAN domains 4
Previous Name	zinc finger protein 307, "zinc finger protein 427"
Location	6p21
Position	chr6:28244623-28252224, -1
External Links	HGNC: 13854 Entrez Gene: 387032 Ensembl: ENSG00000187626 UCSC: uc003nks.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito T., 2014	SNP: rs1233710	The associated SNP in this gene showed significant association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IEA	83
GO:0005634	nucleus	cellular component	IEA	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1233710	chr6:28247668 - 28247668(1)	intron_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7750106		chr6:28255902 - 28255902(1)	upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_123	chr6:27870166-28498379 (Affymetrix SNP 6.0 array reference genome)	628213		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
24888570	The associated SNP in this gene showed no significant association with SZ.	Negative

Gene relationship with MDD

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Region: chr6:28244623..28252224 View in gBrowse