Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	AHR
Symbol Alias	bHLHe76
Approved Name	aryl hydrocarbon receptor
Location	7p15
Position	chr7:17298622-17346152, 1
External Links	HGNC: 348 Entrez Gene: 196 Ensembl: ENSG00000106546 UCSC: uc011jxz.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		AHR has been related to antipsychotic drugs [43] and Alzheimerâ€™s disease.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 39)

GO terms by PBA (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	IDA[10395741]	7
GO:0003677	DNA binding	molecular function	IDA[15681594]; TAS[19538249]	83
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0005634	nucleus	cellular component	IDA[10395741]	283
GO:0004871	signal transducer activity	molecular function	IEA	32
GO:0030522	intracellular receptor signaling pathway	biological process	IDA[10395741]	8
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[11782478]	66

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008134	transcription factor binding	molecular function	IPI[9079689]	28
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[15681594]	21
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	molecular function	IEA	7
GO:0032922	circadian regulation of gene expression	biological process	ISS	22
GO:0034753	nuclear aryl hydrocarbon receptor complex	cellular component	IBA	2
GO:0035326	enhancer binding	molecular function	IDA[23275542]	1
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS	58
GO:0001568	blood vessel development	biological process	NAS[19538249]	3
GO:0030888	regulation of B cell proliferation	biological process	IDA[15681594]	1
GO:0006915	apoptotic process	biological process	TAS[12213388]	39
GO:0010468	regulation of gene expression	biological process	IDA[15681594]	6
GO:0070888	E-box binding	molecular function	ISS	7
GO:0009410	response to xenobiotic stimulus	biological process	IDA[7961644]	2
GO:0006805	xenobiotic metabolic process	biological process	TAS[19538249]	19
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	biological process	IEA	1
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IBA	91
GO:0046983	protein dimerization activity	molecular function	TAS[19538249]	19
GO:0007049	cell cycle	biological process	IEA	6
GO:0051879	Hsp90 protein binding	molecular function	IDA[9079689]	4
GO:0009636	response to toxic substance	biological process	IDA[7961644]	12
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[10395741]	62
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0034752	cytosolic aryl hydrocarbon receptor complex	cellular component	TAS[19538249]	1
GO:0030850	prostate gland development	biological process	IEA	2
GO:0005667	transcription factor complex	cellular component	TAS[19538249]	18
GO:0005515	protein binding	molecular function	IPI[10395741]	563
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[10395741]	31
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[15681594]	17
GO:0045892	negative regulation of transcription, DNA-templated	biological process	ISS	43
GO:0046982	protein heterodimerization activity	molecular function	TAS[19538249]	42

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
acrPathway	Ahr Signal Transduction Pathway	2

Gene related interactors from protein-protein interactions data in HPRD (count: 24)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AHR	ARNTL	YES	in vivo;yeast 2-hybrid	9079689
AHR	NR2F1	NO	in vitro	10620335
AHR	AIP	NO	in vitro;in vivo;yeast 2-hybrid	9083006 , 10986286 , 9111057 , 9837941 , 7961671 , 12065584
AHR	RB1	NO	in vitro;in vivo	9712901 , 11259609
AHR	RELA	NO	in vivo	12181450 , 11114727
AHR	AR	NO	in vivo	17392787
AHR	NCOA1	NO	in vitro;in vivo;yeast 2-hybrid	12024042
AHR	SMARCA4	NO	in vitro	11805098
AHR	HSP90AA1	YES	in vivo	9083006 , 7961671
AHR	NCOA2	NO	in vitro	15641800
AHR	CCNT1	NO	in vitro;in vivo;yeast 2-hybrid	12917420
AHR	XPO1	NO	in vitro;in vivo	12065584
AHR	CUL4B	NO	in vivo	17392787
AHR	ESR1	YES	in vivo	12612060 , 10620335 , 17392787
AHR	NRIP1	YES	in vitro;in vivo	10428779
AHR	EP300	NO	in vivo	10999956
AHR	DAP3	NO	in vitro	10903152
AHR	TAF4	NO	in vitro	15641800
AHR	TBP	YES	in vivo;yeast 2-hybrid	8794892
AHR	NEDD8	NO	in vitro;in vivo	12215427
AHR	TAF7	NO	in vitro;yeast 2-hybrid	8794892
AHR	PTGES3	NO	in vitro;in vivo	11259606 , 11013261
AHR	GTF2F2	NO	in vivo	8794892
AHR	ARNT	NO	in vitro;in vivo;yeast 2-hybrid	8384309 , 7488247 , 7628454 , 11768231 , 12024042

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p21.1	chr7:16500000-20900000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:17298622..17346152 View in gBrowse