Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NME7
Symbol Alias	FLJ37194, NM23-H7, CFAP67
Approved Name	NME/NM23 family member 7
Previous Name	non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Name Alias	cilia and flagella associated protein 67
Location	1q24.2
Position	chr1:169132531-169367967, -1
External Links	HGNC: 20461 Entrez Gene: 29922 Ensembl: ENSG00000143156 UCSC: uc001gfu.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs3766084	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007420	brain development	biological process	IEA	25

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003351	epithelial cilium movement	biological process	IEA	1
GO:0036064	ciliary basal body	cellular component	IEA	8
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005813	centrosome	cellular component	IDA[21399614]	34
GO:0007368	determination of left/right symmetry	biological process	IEA	3
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway	biological process	IEA	1
GO:0006183	GTP biosynthetic process	biological process	IEA	1
GO:0006165	nucleoside diphosphate phosphorylation	biological process	IEA	1
GO:0004550	nucleoside diphosphate kinase activity	molecular function	IBA	1
GO:0006241	CTP biosynthetic process	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0006228	UTP biosynthetic process	biological process	IEA	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0060972	left/right pattern formation	biological process	IEA	2
GO:0042073	intraciliary transport	biological process	IEA	1

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00230	Purine metabolism	12

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00240	Pyrimidine metabolism	5

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NME7	NT5C2	YES	yeast 2-hybrid	16189514
NME7	TCHP	NO	yeast 2-hybrid	16189514
NME7	ZNF263	NO	yeast 2-hybrid	16189514
NME7	KRT18	NO	yeast 2-hybrid	16189514
NME7	FKBP6	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 27)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3766084	chr1:169269320 - 169269320(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 26)

rs_ID	Location	Functional Annotation
rs1320964	chr1:169145229 - 169145229(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1320966	chr1:169145900 - 169145900(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs16861997	chr1:169189742 - 169189742(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3766075	chr1:169204549 - 169204549(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs35527028	chr1:169137742 - 169137742(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs36040633	chr1:169211689 - 169211689(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs41442344	chr1:169214052 - 169214052(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12748624	chr1:169220533 - 169220533(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs6675220	chr1:169221368 - 169221368(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1208373	chr1:169205958 - 169205958(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs1080268	chr1:169207159 - 169207159(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3753299	chr1:169207781 - 169207781(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs16828165	chr1:169209334 - 169209334(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs2066001	chr1:169314888 - 169314888(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16862081	chr1:169306034 - 169306034(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs3213586	chr1:169324602 - 169324602(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs3213587	chr1:169324588 - 169324588(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16862051	chr1:169260942 - 169260942(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs3766083	chr1:169260089 - 169260089(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7528751	chr1:169268854 - 169268854(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12751379	chr1:169266701 - 169266701(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12752953	chr1:169362932 - 169362932(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12733001	chr1:169325561 - 169325561(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs4140538	chr1:169325540 - 169325540(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16862097	chr1:169362463 - 169362463(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4140539	chr1:169325756 - 169325756(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)
1q24.2-q25.1	chr1:167200000-176100000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:169132531..169367967 View in gBrowse