Gene Report

Basic Info
Approved Symbol HTR4
Symbol Alias 5-HT4
Approved Name 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Previous Name 5-hydroxytryptamine (serotonin) receptor 4
Location 5q31-q33
Position chr5:148451032-148677235, -1
External Links HGNC: 5299
Entrez Gene: 3360
Ensembl: ENSG00000164270
UCSC: uc021yfj.1
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs2278392 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Ohtsuki, T.,2002 Haplotype: (HTR4_SVRSNP1) - (HTR4_SVRSNP4)(C-A), (HTR4_SVRSNP1) - (HTR4_SVRSNP4)(C-G), (HTR4_SVRSNP1) - (HTR4_SVRSNP4)(T-G)
These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 4)

GO terms by database search (count: 11)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 10)

Literature-origin SNPs (count: 2)

LD-proxies (count: 8)

Gene related CNVs (count: 0)

Gene related other variants (count: 8)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr5:148451032..148677235 View in gBrowse
View in gBrowse