Gene Report

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Basic Info

Approved Symbol	TM9SF2
Symbol Alias	P76
Approved Name	transmembrane 9 superfamily member 2
Location	13q32.2
Position	chr13:99501417-99564006, 1
External Links	HGNC: 11865 Entrez Gene: 9375 Ensembl: ENSG00000125304 UCSC: uc001voj.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs9554603	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	TAS[9729438]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006810	transport	biological process	TAS[9729438]	47
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19199708]	176
GO:0010008	endosome membrane	cellular component	IEA	17
GO:0005768	endosome	cellular component	TAS[9729438]	27

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TM9SF2	RAB9A	NO	in vitro;yeast 2-hybrid	9230071
TM9SF2	SMAD4	NO	yeast 2-hybrid	15231748

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9554603	chr13:99494828 - 99494828(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q32	chr13:98700000-101100000	9 (2/3/4)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr13:99501417..99564006 View in gBrowse